【摘要】 目的观察益气活血、温阳通络法辅助西医对2型糖尿病周围神经病变患者糖脂代谢、血液流变学和肌电图的影响。方法将2017年8月—2018年11月在石家庄市中医院治疗的160例2型糖尿病周围神经病变患者随机分为2组,对照组80例给予降糖、调脂、营养神经等常规治疗,观察组80例在对照组治疗基础上加用益气活血、温阳通络法治疗,2组疗程均为8周。记录2组治疗前后中医症状积分及糖脂代谢、血液流变学和肌电图指标,统计2组临床疗效。结果 2组治疗后肢体麻木、肢体疼痛、感觉异常、身倦乏力、气短懒言、自汗畏风积分和总积分及空腹血糖(FPG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、全血黏度(高切、低切)、血浆黏度、血细胞比容、纤维蛋白原水平均明显降低(P均<0.05),高密度脂蛋白胆固醇(HDL-C)水平明显升高(P均<0.05),右腓神经和正中神经的感觉神经传导速度(SNCV)、运动神经传导速度(MNCV)均明显增快(P均<0.05),治疗后观察组以上指标改善情况均明显优于对照组(P均<0.05);观察组治疗总有效率为90.0%(72/80),对照组为71.2%(57/80),观察组明显高于对照组(P<0.05)。结论益气活血、温阳通络法辅助西医治疗可显著改善2型糖尿病周围神经病变患者临床症状、糖脂代谢、血液流变学和神经传导速度。更多还原

【Abstract】 Objective It is to observe the effects of the therapy for supplementing qi and activating blood, warming yang and unblocking collaterals on glucose and lipid metabolism, hemorheology and electromyogram of patients with type 2 diabetic peripheral neuropathy. Methods 160 patients with type 2 diabetic peripheral neuropathy treated in Shijiazhuang Hospital of Traditional Chinese Medicine from August 2017 to November 2018 were randomly divided into 2 groups. The control group(n=80) was given conventional treatments such as hypoglycemic therapy, lipid regulation, and nerve nutrition, the observation group(n=80) was treated with the therapy for supplementing qi and activating blood, warming yang and unblocking collaterals on the basis of the treatment of the control group. The treatment course of the two groups was 8 weeks. The TCM syndrome scores, indexes of glucose and lipid metabolism, hemorheology and electromyography before and after treatment in the 2 groups were recorded, and the clinical effects of the 2 groups were evaluated. Results After treatment, the TCM scores of limb numbness, limb pain, paresthesia, fatigue, shortness of breath, spontaneous sweating, wind-fearing and total score, levels of fasting blood glucose(FPG), postprandial 2 h blood glucose(2 hPG), glycosylated hemoglobin(HbA1 c), total cholesterol(TC), triacylglycerol(TG), low-density lipoprotein cholesterol(LDL-C), whole blood viscosity(high-cut, low-cut), plasma viscosity, hematocrit, fibrinogen were significantly reduced(P<0.05), the level of high-density lipoprotein cholesterol(HDL-C) was significantly increased(P<0.05), the sensory nerve conduction velocity(SNCV) and motor nerve conduction velocity(MNCV) of the right peroneal and median nerves were significantly increased(P<0.05), the improvement of the above indicators in the observation group was significantly better than that of the control group(P<0.05); the total effective rate of treatment in the observation group was 90.0%(72/80), and that in the control group was 71.2%(57/80), the observation group was significantly higher than the control group(P<0.05). Conclusion The assistant treatment with the Chinese drugs for supplementing qi and activating blood, warming yang and unblocking collaterals of replenishing qi and activating blood, warming yang and dredging collaterals can significantly improve the clinical symptoms, glucose and lipid metabolism, blood rheology and nerve conduction velocity in patients with type 2 diabetic peripheral neuropathy.更多还原