【摘要】 目的:分析重复经颅磁刺激联合奥氮平治疗难治性精神分裂症的临床疗效。方法:选取我院于2017年3月-2018年3月期间收治难治性精神分裂症患者86例为研究对象,按照随机数字分组法将分为两组(观察组和对照组),各43例。对照组予以无抽搐电休克联合奥氮平治疗;观察组予以重复经颅磁刺激联合奥氮平治疗。比较两组治疗效果及安全性。结果:治疗前两组评分差异无统计学含义(P>0.05),治疗后两组阳性与阴性症状量表(PANSS)评分均有所下降,且观察组PANSS评分低于对照组(P<0.05)。观察组治疗总有效率高于对照组(95.35%>81.40%),差异有统计学意义(χ2=4.074,P<0.05);观察组不良反应发生率明显低于对照组(6.98%<23.26%),差异有统计学意义(χ2=4.441,P<0.05)。结论:采用重复经颅磁刺激联合奥氮平治疗难治性精神分裂症,可进一步提高临床疗效,且治疗安全性高,值得临床上加以推广和应用。更多还原

【Abstract】 Objective: To analyze the clinical efficacy of repetitive transcranial magnetic stimulation combined with olanzapine in the treatment of refractory schizophrenia.Methods: a total of 86 patients with refractory schizophrenia admitted to our hospital from March 2017 to March 2018 were selected as study subjects.According to the random number grouping method, they were divided into two groups(observation group and control group),with 43 cases each.The control group was treated with convulsion-free electroconvulsive therapy combined with olanzapine.The observation group was treated with repeated transcranial magnetic stimulation combined with olanzapine.The efficacy and safety of the two groups were compared.Results:There was no statistically significant difference in scores between the two groups before treatment(P>0.05).PANSS scores of both groups decreased after treatment,and PANSS scores of the observation group were lower than those of the control group(P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group(95.35%>81.40%),and the difference was statistically significant( χ2=4.074,P<0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group(6.98%<23.26%),with statistically significant difference(χ2=4.441,P<0.05).Conclusion:Repetitive transcranial magnetic stimulation combined with olanzapine in the treatment of refractory schizophrenia can further improve the clinical efficacy,and the treatment safety is high,worthy of clinical promotion and application.更多还原