【摘要】 目的:探讨药物性肝病(DILD)的治疗种类、临床特点以及防治措施。方法:2016年10月-2018年10月纳入来我院就诊的老年DILD患者100例,对所有老年患者的临床相关资料进行充分分析。结果:对于老年患者,常使用多种药物联合使用,对其肝脏功能极易造成损伤,临床上心血管药物应用较高,其所占比例为38.00%(38/100);位居第二的抗肿瘤药物,其所占比例为26.00%(26/100);抗生素药物所占比例为20.00%(20/100);其临床症状主要包含呕吐、恶心、纳差、疲乏等,其所占比例为30.00%(30/100),黄疸所占比例为18.00%(18/100),皮肤瘙痒所占比例为12.00%(12/100),低热所占比例为10.00%(10/100),无症状患者所占比例为30.00%(30/100)。结论:对于老年DILD患者常使用抗肿瘤药物、抗生素以及心血管疾病药物治疗,老年患者肝功能损伤后无明显临床症状,老年DILD相关肝脏药物代谢酶活性明显下降,长时间联合用药会加重病情发展。更多还原

【Abstract】 Objective: to explore the types of treatment, clinical features, prevention and treatment of drug-induced liver disease in the elderly. methods: from October 2016 to October 2018,100 elderly patients with drug-induced liver disease were included in our hospital, and the clinical data of all elderly patients were fully analyzed. Results: for the elderly patients, the combined use of many drugs from time to time was very easy to damage their liver function, and cardiovascular drugs were used more frequently in clinical practice, accounting for 38.00%(38/100) Its proportion was 26.00%(26/100), the proportion of antibiotics was 20.00%(20/100), the clinical symptoms mainly included vomiting, nausea, poor reception and fatigue, its proportion was 30.00%(30/100), the proportion of jaundice was 18.00%(18/100), the rate of skin itching was 12.00%(12/100), the rate of low fever was10.00%(10/100), and the rate of asymptomatic patients was 30.00%(30/100). Conclusion: The elderly patients with drug-induced liver disease are often treated with anti-tumor drugs, antibiotics and cardiovascular drugs.Drug-induced liver disease and related liver drug metabolism enzyme activity decreased significantly in the elderly, long-term drug combination will aggravate the disease development.更多还原