【摘要】 观察苦瓜提取物对Ⅱ型糖尿病胰岛素抵抗大鼠糖脂代谢及胰岛功能的影响.采用4周龄SD大鼠,以高脂饲料喂养大鼠16周后,单次给予腹腔小剂量注射链脲佐菌素(STZ)30 mg/kg,建立Ⅱ型糖尿病胰岛素抵抗动物模型,随机分为7组(正常组、模型组、二甲双胍实验组、吡格列酮实验组、苦瓜提取物实验组、二甲双胍-苦瓜提取物组、吡格列酮-苦瓜提取物组),每组12只.比较各药物干预4周后对Ⅱ型糖尿病胰岛素抵抗大鼠体重、饮水、摄食量、空腹血糖(FBG)、甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、游离脂肪酸(FFA)、胰岛素抵抗指数及胰岛β细胞功能的影响.结果表明:苦瓜提取物联合西药能缓解大鼠糖尿病症状(P<0.05)、苦瓜提取物、吡格列酮、苦瓜提取物联合西药可显著降低大鼠FBG;二甲双胍、吡格列酮、苦瓜提取物及苦瓜提取物联合西药均可降低TG、TC、LDL、FFA水平,升高HDL水平(P<0.05),并且能够降低胰岛素抵抗指数,改善胰岛β细胞功能(P<0.05).苦瓜提取物对Ⅱ型糖尿病胰岛素抵抗大鼠的空腹血糖、血脂水平及胰岛功能有一定调节作用.更多还原

【Abstract】 To observe the effects of Momordica charantia L. extract on glucose and lipid metabolism and islet function in type II diabetic insulin resistance rats.Four-week-old SD rats were fed with high-fat diet for 16 weeks.A single intraperitoneal injection of streptozotocin(STZ) 30 mg/kg was given in a single dose to establish an insulin resistance animal model of type 2 diabetes.They were divided into 7 groups(normal group, model group,metformin experimental group,pioglitazone experimental group,bitter gourd extract experimental group,metformin-bitter gourd extract group,pioglitazone-bitter gourd extract group),12 rats in each group.Comparison of insulin resistance in type II diabetes after 4 weeks of drug intervention rat body weight,drinking water,food intake,fasting blood glucose(FBG),triglyceride(TG),cholesterol(TC),low density lipoprotein(LDL-C),high density lipoprotein(HDL-C) free fatty acid(FFA)),insulin resistance index and islet beta cell function.Momordica charantia extract combined with western medicine can alleviate the symptoms of diabetes in rats(P<0.05),bitter melon extract,pioglitazone,bitter gourd extract combined with western medicine can significantly reduce FBG in rats;metformin,pioglitazone,bitter gourd extract and bitter gourd extract combined with western medicine The levels of TG,TC,LDL,and FFA increased HDL levels(P<0.05),and decreased insulin resistance and improved islet β-cell function(P<0.05). Momordica charantia can regulate the fasting blood glucose,blood lipid level and islet function of type 2 diabetic insulin resistance rats.更多还原