【摘要】 人类肠道中含有的多种微生物,称为肠道菌群,它们对宿主的健康起着至关重要的作用。肠道菌群的组成包括细菌、病毒和真核生物,已经被证明与宿主健康有密切的联系,尤其是其中的益生菌。益生菌通过多种途径发挥作用,包括与宿主微生物的相互作用、抵御病原菌的定殖、改善肠道屏障功能、调节免疫功能、产生相关代谢产物,在宿主的代谢、免疫和神经系统中发挥有益作用。综述益生菌的作用机制,讨论了近年来益生菌应用临床研究实例以更好地理解其对疾病风险和健康可持续性的贡献,将为新的治疗干预和疾病预防策略提供参考。更多还原

【Abstract】 In human intestines harbors diverse microbes, called intestinal microbial community(IMC), they play the most important role in the health of their host. The constituents of IMC includes bacteria, viruses, and eucaryotic organisms, they have been proved to have close relation with the host′s health, especially probiotics. Probiotics play their role through many pathways, including the interaction with the host′s microbes, to resist the setting of pathogen, to improve the function of preventive screen of intestines, to regulate the function of immunity, to produce correlated metabolites, they play beneficial role in host′s metabolism, immunity, and nervous system. This paper summarizes the functional mechanism of probiotics, discusses the recent clinical study application cases of probiotics so as to better understand the distribution of probiotics on the risk of diseases and the sustainability of health, and will point out a road for new therapeutic interfering in and diseases prevention tactics.更多还原