【摘要】 目的探讨交替应用洛芬待因与吗啡在吗啡耐药癌痛患者中的应用效果与安全性。方法选取2018年1月—2019年1月于本院就诊的80例吗啡轻度耐药癌痛患者,随机分为观察组与对照组,对照组40例采用吗啡缓解突破性疼痛,观察组40例采用洛芬待因与吗啡交替服用治疗,比较两组癌痛镇痛效果及不良反应发生情况。结果观察组2周、2个月、6个月时吗啡耐受需增量率低于对照组(P <0.05),并且观察组疼痛数字评分(numerical rating scale,NRS)、生活质量评分(quality of life score,QOL)均优于对照组(P<0.05);观察组不良反应发生率明显低于对照组(P <0.05)。结论洛芬待因与吗啡交替应用可显著提升吗啡轻度耐药癌痛患者镇痛效果。更多还原

【Abstract】 Objective To explore the effect and safety of alternate application of codeine and morphine in patients with morphine-resistant cancer pain. Methods From January 2018 to January 2019, selected 80 patients with mildly resistant morphine cancer pain,randomly divided into observation group and control group, and 40 cases in control group were treated with morphine to relieve breakthrough pain. 40 patients were treated alternately with ibuprofen and morphine, compared the analgesic effect and adverse reactions of cancer pain between the two groups. Results The increase rate of morphine tolerance, numerical rating scale(NRS) and quality of life score(QOL), the incidence of adverse reactions were significantly lower in the observation group at 2 weeks, 2 months, and 6 months(P < 0.05). Conclusion The alternate application of codeine and morphine can significantly improve the analgesic effect of patients with mildly resistant morphine cancer pain.更多还原