【摘要】 目的探讨不同Sourtherland疾病活动指数溃疡性结肠炎的肠道菌群失调与不同免疫球蛋白水平相关性分析。方法选择从2017年8月—2018年8月收治的200例溃疡性结肠炎患者为对象,按照Sourtherland疾病活动指数评分划分为四组。结果中度活动组及重度活动组的IgM高于症状缓解组(P <0.05);轻度活动组、中度活动组及重度活动组的C3、C4高于症状缓解组(P <0.05);经Pearson相关性分析发现,溃疡性结肠炎患者中血清IgG与其病情无相关关系(P> 0.05),而血清IgM与其病情表现为正相关关系(P <0.01)。结论溃疡性结肠炎患者的免疫球蛋白水平IgM含量、IgA含量与其病情严重程度存在直接相关性,可作为临床疾病诊断以及病情判断的参考指标。更多还原

【Abstract】 Objective To study the relationship between intestinal flora disorder and immunoglobulin level in ulcerative colitis with different disease activity index of Southerland. Methods 200 patients with ulcerative colitis from August 2017 to August 2018 were selected as subjects, and divided into four groups according to the Southerland disease activity index. Results The Ig M of moderate activity group and severe activity group was higher than that of symptom relief group(P < 0.05); the C3 and C4 of mild activity group, moderate activity group and severe activity group were higher than that of symptom relief group(P < 0.05). There was no difference in C4 between mild and moderate activity group and symptom relief group(P > 0.05);The Pearson correlation analysis showed that there was no correlation between serum Ig G and the condition of ulcerative colitis(P > 0.05),There was a positive correlation between serum Ig M and the disease(P < 0.01). Conclusion There is a direct correlation between the LGM and Ig A levels of patients with ulcerative colitis and the severity of the disease, which can be used as a reference index for clinical diagnosis and disease judgment.更多还原