【摘要】 非甾体抗炎药(NSAIDs)是全球使用最广泛的药物之一,主要用于治疗发热、急性或慢性疼痛、炎性疾病和风湿免疫性疾病。长期服用NSAIDs可导致NSAIDs相关性胃肠病的发生,以NSAIDs胃病多见,临床常表现为胃肠道炎症、胃肠道溃疡、胃肠出血、蛋白质丢失性肠病、回肠吸收功能障碍、肠通透性升高、穿孔、梗阻、狭窄等。由于NSAIDs相关性胃肠病临床表现隐匿,内镜下表现多发、多变而无特异性,容易导致漏诊和误诊。近期我院收治1例因腹痛、纳差、乏力和低蛋白血症患者,经过多次胃肠镜及胶囊内镜检查和追问病史,最后诊断为NSAIDs隔膜、NSAIDs相关性胃肠病,诊治过程复杂,现报道如下,以提高临床医师对该病的认识。更多还原

【Abstract】 Non-steroidal anti-inflammatory drugs(NSAIDs) are one of the most widely used drugs in the world, mainly used to treat fever, acute or chronic pain and inflammatory and rheumatic immune diseases. Long-term use of NSAIDs can lead to the occurrence of NSAIDs-related gastrointestinal diseases, most of which are NSAIDs gastropathy, and its clinical manifestations are gastrointestinal inflammation, gastrointestinal ulcer, gastrointestinal bleeding, protein-losing enteropathy, ileum absorptive dysfunction, intestinal permeability elevation, perforation, obstruction, stenosis, etc. Due to the insidious clinical manifestations of NSAIDs-related gastrointestinal diseases and the multiple, variable and non-specific manifestations under endoscopy, it is easy to lead to missed diagnosis and misdiagnosis. Recently, a case of hypoproteinemia with abdominal pain, poor appetite, weakness was admitted to our hospital. After repeated gastroenteroscopy and capsuleendoscopy, and follow-up medical history, the final diagnosis was NSAID-induced diaphragmatic disease, NSAIDs-related gastrointestinal diseases, and the diagnosis and treatment process was complex. The report was as follows to improve clinicians’ understanding of this disease.更多还原