【摘要】 目的探讨中性粒细胞与淋巴细胞比值与2型糖尿病肾病进展的相关性。方法 2014年9月—2016年12月间采用回顾性队列研究纳入2型糖尿病患者492例,据24 h尿蛋白总量将492例2型糖尿病患者分为糖尿病无肾病组(DM组)424例,糖尿病肾病组(DN组)68例。收集其临床资料,追踪其3年后DN进展情况。将基线中性粒细胞与淋巴细胞比值(NLR)水平按四分位法分为四组,即最低四分位数组(I组)≤1.37、第二四分位数组(II组)1.38～1.83、第三四分位数组(III组)1.84～2.21、最高4分位数组(IV组)≥2.22。按DN是否进展,将研究对象分为进展组(A组)和未进展组(B组),比较两组基线资料,采用二元Logistic回归,评估糖尿病病程、SBP、HbA1c、BMI及基线NLR水平与DN进展之间的相关性。结果 3年后,64例(13.00%)患者糖尿病肾病进展,其中新发糖尿病肾病42例(8.53%)。单因素分析中,A组与B组相比较,年龄、病程、BMI、收缩压、NLR、FPG、HbA1c、TC、TG差异有统计学意义(P<0.05)。结论 NLR水平>1.83是T2DM患者DN进展的独立危险因素。更多还原

【Abstract】 Objective To investigate the correlation between the ratio of neutrophils and lymphocytes and the progression of type 2 diabetic nephropathy. Methods From September 2014 to December 2016 a retrospective cohort study was used to enroll 492 patients with type 2 diabetes. According to the total amount of 24 hours urine protein, 492 patients with type 2 diabetes were divided into diabetic nephropathy group(DM group) 424 and diabetic nephropathy group(DN group) 68 patients. Collect clinical data and track the progress of DN after 3 years. The baseline neutrophil-lymphocyte ratio(NLR)levels were divided into four groups according to the quartile, that is, the lowest quartile array(group I) ≤ 1.37, and the second quartile array(group II) 1.38 to 1.83; the third fourth quartile array(Group III) 1.84 to 2.21, the highest quartile array(Group IV) ≥ 2.22. According to whether DN progressed, the study subjects were divided into progress group(group A) and non-progressive group(group B). Baseline data of the two groups were compared, and binary logistic regression was used to evaluate the duration of diabetes, SBP, Hb A1 c, BMI, and baseline NLR levels, correlation with DN progress.Results After 3 years, diabetic nephropathy progressed in 64 patients(13.00%), including 42 newly diagnosed diabetic nephropathy(8.53%). In univariate analysis, there were significant differences in age, disease duration, BMI, systolic blood pressure, NLR, FPG, HbA1 c, TC, and TG in group A compared with group B(P<0.05). Conclusion NLR level> 1.83 is an independent risk factor for DN progression in patients with T2 DM.更多还原