【摘要】 放射治疗(Radiation therapy,RT)是肿瘤常用的治疗手段,是多种放射源的重要组成部分。RT通过杀死肿瘤细胞为肿瘤治疗做出了重大贡献。然而,肠道等快速更新的组织是人体对辐射最敏感的器官,在腹腔内或盆腔恶性肿瘤治疗过程中,不可避免受到照射,随后表现为放射性肠损伤。目前,广为接受的辐射损伤防护假说涉及经典Wnt信号通路(即Wnt/β-catenin),激活Wnt/β-catenin信号通路能保护肠道上皮免受辐射损伤,其潜在的机制包括诱导肠道隐窝干细胞再生、清除ROS等。本文就肠道放射性损伤特点、经典Wnt信号通路及其在放射性肠损伤中的研究进展作一综述。更多还原

【Abstract】 Irradiation from diverse sources is ubiquitous and closely associated with human activities.Radiation therapy(RT),an important component of multiple radiation origins,is a common therapeutic modality for cancer.More importantly,RT provides significant contribution to oncotherapy by killing tumor cells.But,Intestinal tract and other rapidly updated tissues are the most sensitive organs to radition in th human body,in the treatment of abdominal or pelvic malignancy,and it is inevitable to be irradiated,then followed by the performance of radiation-induced intestinal injury.At present,the widely accepted hypothesis for protection against radiation-caused injury involves the Wnt canonical pathway(Wnt/β-catenin).Activating the Wnt/β-catenin signaling pathway may protect the intestinal epithelium from radiation damage.The underlying mechanisms include inducting of intestinal crypt stell regeneration,ROS clearance et al.In this paper,the characteristics of gastrointestinal radiation,the canonical Wnt pathway and its research progress in gastrointestinal radiation,damage are reviewed.更多还原