【摘要】 目的基于生物信息学视角探讨子宫内膜异位症与不孕症的关联。方法挖掘五类疾病-基因信息数据库平台获取子宫内膜异位症与不孕症的共同相关基因,并对其进行基因富集可视化以及构建蛋白互作网络图。结果子宫内膜异位症与不孕症的共有基因为366个。将其共有基因导入Metascape平台进行富集分析,发现两类疾病的共有通路主要集中在生殖结构发育、细胞因子介导的信号通路、癌症相关通路、细胞增殖负调控、类固醇代谢过程等;参与的蛋白质互作网络主要有15类模块子结构,参与蛋白最多的模块子结构最相关的三大通路为PD-1信号通路、CD28家族的共同刺激途径、Th17细胞分化。结论子宫内膜异位症与不孕症包含大量交叉共有的基因,同时其基因也共同作用于多个相关功能通路与生物过程,提示两类疾病之间存在着密切关联的机制,可为药物治疗提供共同靶点。更多还原

【Abstract】 Objective:To explore the relationship between endometriosis and infertility from a bioinformatics perspective.Methods:Mining five types of diseases-gene information database to obtain common related genes of endometriosis and infertility,these genes were enriched and visualized and the protein interaction network diagrams were constructed.Results:A total of 366 common genes related endometriosis and infertility were introduced into the Metascape platform for enrichment analysis. It was found that the common pathways of the two diseases were mainly focused on reproductive structure development,cytokine-mediated signaling pathway,pathways related cancer,negative regulation of cell proliferation,steroid metabolic process,etc. The protein-protein interaction networks were mainly composed of 15 kinds of functional modules. The three most related pathways with the largest number of proteins were PD-1 signaling pathway,CD28 family co-stimulation pathway and Th17 cell differentiation.Conclusions:Endometriosis and infertility contain a large number of cross-shared genes. The genes act on multiple related signaling pathways and biological process,suggesting that there is a close relationship between the two diseases,which may provide a common target for drugs therapy.更多还原