【摘要】 卵母细胞衰老是女性自然衰老的开始,在分子层面了解导致卵母细胞衰老的原因和机制,对于抑制与年龄相关的疾病和促进女性健康长寿至关重要。本文对卵母细胞衰老的分子病因机制,从基因组的完整性和稳定性、线粒体功能障碍、端粒缩短、DNA损伤修复、表观遗传学改变、以及神经内分泌级联反应等几个方面展开详细综述。更多还原

【Abstract】 Oocyte aging is beginning of natural aging of women. Understanding the causes and mechanisms of oocyte aging at the molecular level is essential for controlling age-related diseases and promoting healthy and long life of women. This paper reviews the molecular pathogenesis of oocyte aging in detail from the aspects of genome integrity and stability,mitochondrial dysfunction,telomere shortening,DNA damage repair,epigenetic changes,and neuroendocrine cascade reaction.更多还原