【摘要】 目的 :观察并探讨麝香保心丸对2型糖尿病患者尿微量白蛋白的作用。方法 :收集2016年7月至2017年1月复旦大学附属华山医院东院收治的2型糖尿病患者68例,随机分成对照组和中药组各34例。对照组予以基础治疗,中药组在对照组基础上服用麝香保心丸,治疗6个月后检测并比较两组患者身体质量指数(BMI)、腰臀比(WHR)、血压、空腹血糖(FBG)、血脂、肾功能、高敏C反应蛋白(hs-CRP)和尿微量白蛋白/肌酐比(UACR)等指标。结果:治疗后,中药组血胆固醇(TC)、低密度脂蛋白(LDL-C)水平明显低于对照组(P <0.05),hs-CRP和UACR较对照组也明显降低(P <0.05)。结论 :麝香保心丸能改善2型糖尿病患者微量白蛋白尿,其机制可能与降低hs-CRP、改善内皮细胞功能有关。更多还原

【Abstract】 Objective: To observe and explore the effect of Shexiangbaoxin pill on urine microalbumin in patients with type 2 diabetes(T2 D). Methods: Sixty-eight T2 D patients, who were admitted into East Courtyard of Huashan Hospital affiliated to Fudan University from July 2016 to January 2017, were collected and randomly divided into a control group and a Chinese medicine group with 34 cases in each group. The control group received the basic treatment, while the Chinese medicine group took Shexiangbaoxin pill on the basis of the control group. After 6 months of treatment, the indexes such as body mass index(BMI), waist-to-hip ratio(WHR), blood pressure(BP), fasting blood glucose(FBG), blood lipids, renal function, high-sensitivity C-reactive protein(hsCRP) and urine microalbumin/creatinine ratio(UACR) and other indicators were compared between the two groups. Results: After treatment, the levels of blood total cholesterol(TC) and low density lipoprotein-cholesterol(LDL-C) in the Chinese medicine group were significantly lower than those in the control group(P<0.05), and hs-CRP and UACR in the Chinese medicine group were also significantly lower than those in the control group(P<0.05). Conclusion: Shexiangbaoxin pill can improve microalbuminuria in patients with type 2 diabetes, and the mechanism may be related to reducing hs-CRP and improving endothelial cell function.更多还原