【摘要】 目的探究显微外科手术治疗矢状窦旁脑膜瘤对环氧化酶-2及症状改善率的影响。方法选取90例矢状窦旁脑膜瘤患者,并随机分成2组,每组45例。一组为对照组,采用传统开颅手术治疗;另一组为观察组,采用显微外科手术治疗。观察比较2组患者的手术情况,术后症状改善情况,环氧化酶-2水平,肿瘤切除Simpson分级情况,以及并发症发生情况和复发率情况。结果观察组患者的术中出血量明显低于对照组(P <0. 05)。治疗后,观察组患者的癫痫、四肢运动、感觉障碍症状发生率分别为4. 44%、2. 22%、2. 22%,明显低于对照组的33. 33%、15. 56%、24. 44%(P <0. 05)。治疗后,观察组患者的环氧化酶-2水平明显低于对照组(P <0. 05)。治疗后,观察组患者的肿瘤SimpsonⅠ级、SimpsonⅡ级、SimpsonⅢ级切除率,明显优于对照组患者(P <0. 05)。治疗后,观察组患者的颅内出血发生率2. 22%、癫痫发作为0,明显低于对照组的颅内出血发生率26. 67%、癫痫发作率20%(P <0. 05)。观察组患者的复发率为0,明显低于对照组患者22. 22%(P <0. 05)。结论显微外科手术治疗矢状窦旁脑膜瘤患者,能够明显改善患者的临床症状,降低环氧化酶-2水平,减少并发症和复发率,提高治疗效果。更多还原

【Abstract】 Objective To explore the effects of microsurgery on cyclooxygenase-2 and symptom improvement rate in the treatment of parasagittal meningioma. Methods 90 patients with parasagittal meningioma were selected,and they were randomly divided into 2 groups,each group had 45 cases. The control group received conventional craniotomy,the observation group was treated with microsurgery. The surgical conditions,postoperative symptom improvement,level of cyclooxygenase-2 and Simpson grading of tumor resection and the incidence and recurrence rate of complications in the 2 groups were observed and compared.Results The intraoperative blood loss in the observation group was significantly lower than that of the control group( P < 0. 05).The incidence of epilepsy,limb movement and sensory disturbance in the observation group was 4. 44%,2. 22% and 2. 22%,which were significantly lower than those of the control group( 33. 33%,15. 56%,24. 44%),respectively( P < 0. 05). The level of cyclooxygenase-2 in the observation group was significantly lower than that of the control group( P < 0. 05). After treatment,the tumor Simpson Ⅰ,Simpson Ⅱ and Simpson Ⅲ resection rate of patients in the observation group were significantly better than those of the control group( P < 0. 05). The incidence of intracranial hemorrhage in the observation group were 2. 22%,and epilepsy was 0,which was significantly lower than that of the control group( 26. 67% and 20%)( P < 0. 05). and The recurrence rate in the observation group was 0,which was significantly lower than that of the control group( 22. 22%)( P < 0. 05). Conclusion Microsurgery treating patients with parasagittal meningioma can significantly improve the clinical symptoms of patients,reduce the level of cyclooxygenase-2,reduce the rate of complications and recurrence,and improve the therapeutic effect.更多还原