【摘要】 目的分析创伤性湿肺并发急性呼吸窘迫综合征(ARDS)纤溶患者血清中NF-KB p65表达特点。方法 2017年11月～2018年11月选取宝鸡市中心医院胸外科收治的创伤性湿肺并发ARDS患者62例,设为观察组;另选取同期收治的62例创伤性湿肺患者,设为参考组;选取同期收治的62例轻微肺部损伤患者,设为对照组。入院和治疗1周后,对比三组血NF-KB p65表达、纤维蛋白溶解情况、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)和纤维蛋白原(FIB)水平变化情况。结果入院时,观察组、参考组和对照组血NF-KB p65表达阳性率分别为98.39%,67.74%和9.68%,观察组血NF-KB p65表达阳性率高于参考组和对照组(χ~2=6.023,11.276),参考组高于对照组(χ~2=9.120),差异均有统计学意义(均P<0.05)。观察组纤维蛋白原含量低于参考组和对照组,参考组纤维蛋白原含量低于对照组,观察组凝血酶原时间、活化部分凝血活酶时间和凝血酶时间高于参考组和对照组,参考组凝血酶原时间、活化部分凝血活酶时间和凝血酶时间高于对照组。治疗1周后,观察组、参考组和对照组血NF-KB p65表达阳性率分别为11.29%,9.68%和9.68%,三组血NF-KB p65表达阳性率差异无统计学意义(χ~2=0.062～0.206,均P>0.05);三组纤维蛋白原含量、凝血酶原时间、活化部分凝血活酶时间和凝血酶时间对比,差异均无统计学意义(均P>0.05)。结论创伤性湿肺并发ARDS患者,具有血NF-KB p65表达升高、纤维蛋白原含量下降和凝血功能异常的特征。血NF-KB p65表达可作为评析患者肺部疾病进展和危重程度的可靠指标。更多还原

【Abstract】 Objective To analyze the expression of NF-KB p65 in the serum of patients with traumatic wet Lung complicated with acute respiratory distress syndrome(ARDS) fibrinolysis. Methods From November 2017 to November 2018, 62 patients with raumatic wet Lung complicated with ARDS fibrinolysis admitted to the Thoracic Surgery Department of Baoji Central Hospital were selected as the observation group,another 62 patients with traumatic wet lung admitted at the same time were selected as the reference group,and 62 patients with slight lung injury admitted at the same time were selected as the control group. One week after admission and treatment, the expression of NF KB p65, fibrinolysis, prothrombin time(PT), activated partial thromboplastin time(APTT), thrombin time(TT) and fibrinogen(FIB) were compared among the three groups. Results At the time of admission, the positive rates of NF-KB p65 expression in the blood of the observation group, the reference group and the control group were 98.39%, 67.74% and 9.68%, respectively. The positive rate of p65 expression in the observation group was higher than that in the reference group and the control group, the difference was statistically significant(χ~2=6.023, 11.276, all P < 0.05). The fibrinogen content in the observation group was lower than that in the reference group and the control group, the prothrombin time, activated partial thromboplastin time and thrombin time in the observation group were higher than those in the reference group and the control group, and the clotting time in the reference group was higher than that in the reference group and the control group Prothrombin time, activated partial thromboplastin time and thrombin time were higher than those in the control group. After one week of treatment, the positive rates of NF-KB p65 expression in the observation group, the reference group and the control group were 11.29%, 9.68% and 9.68%, respectively. There was no significant difference in the positive rates of NF-KB p65 expression among the three groups,and there was no significant difference in fibrinogen content, prothrombin time, activated partial thromboplastin time and thrombin time among the three groups(χ~2=0.062～0.206,all P>0.05). Conclusion The patients with ARDS had the characteristics of increased expression of NF KB p65, decreased fibrinogen content and abnormal coagulation function. The expression of NF KB p65 in blood can be used as a reliable index to evaluate the progress and severity of pulmonary disease.更多还原