【摘要】 目的:探究维生素D水平与牛奶蛋白过敏(CMPA)患儿的相关性。方法:选取2018年6月～2020年6月就诊于我院的50例CMPA患儿作为观察组,根据其病情严重程度分为轻度组18例、中度组27例和重度组5例,另选取同期于本院进行健康体检的50例健康婴幼儿作为对照组。检测并比较各组血清25-羟基维生素D [25(OH)D]水平,收集婴幼儿的临床资料,采用单因素和多因素Logistic回归分析CMPA的相关影响因素。结果:观察组患儿血清25(OH)D水平显著低于对照组,差异具有统计学意义(P<0.05);重度组和中度组患儿血清25(OH)D水平显著低于轻度组,而重度组又显著低于中度组,差异具有统计学意义(P<0.05);单因素分析显示,CMPA与血清牛奶蛋白总免疫球蛋白E(IgE)检查结果、血嗜酸性粒细胞检查结果、家族过敏史、维生素D缺乏、喂养方式、生产方式有关(P<0.05),多因素Logistic回归分析显示,血清牛奶蛋白总IgE为阳性、血嗜酸性粒细胞增多、家族过敏史、维生素D缺乏、人工喂养、剖宫产是CMPA的独立影响因素(P<0.05)。结论:CMPA患儿血清25(OH)D水平显著降低,且病情越严重,其水平越低,血清牛奶蛋白总IgE检查结果、血嗜酸性粒细胞检查结果、家族过敏史、维生素D缺乏、喂养方式、生产方式是CMPA的危险因素。更多还原

【Abstract】 Objective: To explore the correlation between vitamin D level and cow’s milk protein allergy(CMPA) in children.Methods: From June 2018 to June 2020, 50 CMPA children in our hospital were selected as the observation group. According to the severity of the disease, they were divided into mild group with 18 cases, moderate group with 27 cases and severe group with 5 cases. In addition, 50 healthy infants and children who had physical examination in our hospital at the same time were selected as the control group. The serum 25 hydroxyvitamin D [25 hydroxyvitamin D, 25(OH) D] level were measured and compared in each group. The clinical data of infants and children were collected, and the CMPA related factors were analyzed by single factor and multi factor Logistic regression. Results: The serum of 25(OH) D level in the observation group was significantly lower than that in the control group, the difference was statistically significant(P<0.05). The serum of 25(OH) d level in the severe group and the moderate group were significantly lower than that in the mild group, while the serum 25(OH) D level in the severe group was significantly lower than that in the moderate group, the differences were statistically significant(P<0.05). Single factor analysis showed that CMPA were associated with serum milk protein serum total immunoglobulin E(IgE) test results, blood eosinophils inspection results, family history of allergies, vitamin D deficiency, feeding mode, production mode(P<0.05), the multi-factor Logistic regression analysis showed that the serum milk protein total IgE was positive, blood eosinophil increased, family history of allergies, vitamin D deficiency, artificial feeding, cesarean section were independent influencing factors the CMPA(P<0.05). Conclusion: The serum 25(OH)D level in CMPA children is significantly decreased,and the more serious the disease is, the lower the level is. The serum milk protein total IgE test results, blood eosinophils inspection results, family history of allergies, vitamin D deficiency, feeding mode, production mode are the risk factors of CMPA.更多还原