【摘要】 目的:探讨急性心力衰竭患者血清Adropin、可溶性ST2受体(s ST2)、半乳糖凝集素-3(Gal-3)水平与预后的关系。方法:选取2015年6月～2019年6月期间内蒙古自治区人民医院收治的154例急性心力衰竭患者纳入心衰组,另选同期在内蒙古自治区人民医院进行健康体检的100例志愿者为对照组。对比心衰组、对照组血清Adropin、s ST2、Gal-3水平,并将心衰组患者按美国纽约心脏病协会(NYHA)心功能分级分为II级组(n=38)、III级组(n=64)、IV级组(n=52),对比三组患者的血清Adropin、s ST2、Gal-3水平。心衰组患者经治疗出院后,根据患者的预后效果分为预后良好组(n=95)和预后不良组(n=59),采用单因素和Logistic多元回归分析急性心力衰竭患者预后不良的影响因素。结果:心衰组血清Adropin、s ST2、Gal-3水平均高于对照组(P<0.05)。心衰组患者中随着心功能分级的升高,患者的血清Adropin、s ST2、Gal-3水平均显著升高(P<0.05)。预后不良患者59例,发生率为38.31%。单因素分析结果显示,预后不良组和预后良好组患者在年龄、性别、体质指数(BMI)、吸烟史、饮酒史、基础疾病、血常规指标的比较无统计学差异(P>0.05)。预后不良组患者的心功能分级、血清Adropin、s ST2、Gal-3水平均高于预后良好组(P<0.05)。Logistic多元回归分析显示,心功能分级为IV级、Adropin≥10ng/mL、s ST2≥150μg/m L、Gal-3≥5μg/L是急性心力衰竭患者预后不良的危险因素(P<0.05)。结论:急性心力衰竭患者血清Adropin、s ST2、Gal-3水平显著升高,并随患者的病情加重而升高,血清Adropin、s ST2、Gal-3水平的变化会影响患者的预后。更多还原

【Abstract】 Objective: To investigate the relationship between serum Adropin, soluble ST2 receptor(s ST2) and galactose lectin-3(Gal-3) levels and prognosis in patients with acute heart failure. Methods: 154 patients with acute heart failure who were admitted to People’s Hospital of Inner Mongolia Autonomous Region from June 2015 to June 2019 were enrolled in the heart failure group, another 100 volunteers who underwent health examination in the same period were selected as the control group. The Adropin, s ST2 and Gal-3 levels in heart failure group and control group were compared. The heart failure group were divided into three groups according to American New York Heart Association(NYHA) classification: class II group(n=38), class III group(n=64) and class IV group(n=52). The Adropin, s ST2 and Gal-3 levels among the three groups were compared. The patients in heart failure were divided into good prognosis group(n=95) and poor prognosis group(n=59) according to the prognosis of patients after discharge. Univariate and Logistic multiple regression were used to analyze the influencing factors of poor prognosis in patients with acute heart failure. Results: Adropin, s ST2 and Gal-3 levels in heart failure group were higher than those in control group(P<0.05). The Adropin, s ST2 and Gal-3 levels in patients with heart failure group increased significantly with the increase of heart function classification(P<0.05). 59 patients had poor prognosis, the incidence was 38.31%. Univariate analysis showed that there were no significant differences in age, gender, body mass index(BMI),smoking history, drinking history, basic diseases and Blood Routine Indexes between the poor prognosis group and the good prognosis group(P>0.05). Cardiac function classification, serum Adropin, s ST2 and Gal-3 levels in patients with poor prognosis group were higher than those in patients with good prognosis group(P<0.05). Logistic multivariate regression analysis showed that class IV, Adropin≥10 ng/m L, s ST2≥150 μg/m L and Gal-3≥5 μg/L were risk factors for poor prognosis in patients with acute heart failure(P<0.05). Conclusion:The serum Adropin, s ST2 and Gal-3 levels in patients with acute heart failure are increased significantly, and they are increased with the aggravation of the disease. The changes of serum Adropin, s ST2 and Gal-3 levels would affect the prognosis of patients.更多还原