【摘要】 目的·探索血清白介素-6(interleukin-6,IL-6)水平与精神分裂症伴抑郁症状之间的关系。方法·招募239例使用奥氮平单药治疗2年以上的精神分裂症患者。采用卡尔加里精神分裂症抑郁量表(Calgary Depression Scale for Schizophrenia,CDSS)评估患者的抑郁水平,并将其分为伴抑郁组和不伴抑郁组。采用阳性与阴性症状量表(Positive and Negative Syndrome Scale,PANSS)评估患者的精神症状。采用酶联免疫吸附测定(enzyme linked immunosorbent assay,ELISA)检测血清IL-6水平,并进行组间比较。采用Pearson相关分析检验血清IL-6水平与CDSS评分之间的关系。结果·依据CDSS评分结果将患者分为伴抑郁组(119例)和不伴抑郁组(120例)。与不伴抑郁组相比,伴抑郁组患者的PANSS阴性症状分量表评分、血清IL-6水平均较高(P=0.028,P=0.000)。经Pearson相关分析显示,伴抑郁组患者的血清IL-6水平与CDSS评分呈正相关(r=0.42,P=0.000)。结论·血清IL-6水平增高可能与精神分裂症伴抑郁症状的发生有关。更多还原

【Abstract】 Objective · To explore the relationship between serum interleukin-6 (IL-6) level and depressive symptoms in schizophrenia.Methods · A total of 239 patients with schizophrenia treated with olanzapine alone for more than 2 years were enrolled.Calgary Depression Scale for Schizophrenia (CDSS) was used to evaluate the depression level of the patients,and they were divided into depression group and non-depression group.Positive and Negative Syndrome Scale (PANSS) was used to evaluate the mental symptoms of patients.Serum IL-6 levels were measured by enzyme linked immunosorbent assay (ELISA),and the differences between the two groups were compared.Pearson correlation analysis was used to analyze the relationship between serum IL-6 level and CDSS score.Results · According to the results of CDSS,the patients were divided into depression group (119 cases) and non-depression group (120 cases).Compared with the non-depression group,the PANSS negative symptom subscale score and serum IL-6 level of patients in the depression group were higher (P=0.028,P=0.000).Pearson correlation analysis showed that serum IL-6 level was positively correlated with CDSS score in the depression group patients (r=0.42,P=0.000).Conclusion · The increase of serum IL-6 level may be related to the occurrence of schizophrenia with depression symptoms.更多还原