【摘要】 以三乙胺为溶剂,二硫化碳和氨基硫脲在78～80℃反应1.5 h,得到2-氨基-5-巯基-1,3,4-噻二唑,产率69%,再将其与取代苯甲醛反应,得到一系列的2-氨基-5-巯基-1,3,4-噻二唑席夫碱5a～5f,产率66%～83%,所得化合物结构经1HNMR、13CNMR、FT-IR和HRMS验证.生物活性测试表明,化合物5f对番茄灰霉病菌、油菜菌核病菌和大豆灰斑病菌的有较高的抑制作用.更多还原

【Abstract】 With triethylamine as solvent,carbon disulfide and thiourea were reacted at 78 ～ 80 ℃ for 1. 5 h to give2-amino-5-thiol-1,3,4-thiazolyldiazole,yield 69%. Then a series of 2-amino-5-mercapto-1,3,4-thiiodiazole schiff base derivatives 5 a ～ 5 f were synthesized via the condensation reaction of 2-amino-5-thiol-1,3,4-thiazolyldiazole and substituted benzaldehyde with the yield 66% ～ 83%. The structures of the synthesized compounds were identified by means of 1 H NMR,13 C NMR,FT-IR and HRMS techniques. Preliminary bioactivity tests showed that compound 5 f had a high inhibitory effect on Tomato Botrytis Cinerea,Rape Sclerotinia Sclerotiorum and Cercospora Sojina Hara.更多还原