【摘要】 目的探讨男性缺陷型精神分裂症(DS)与非缺陷型精神分裂症(NDS)患者抗心磷脂抗体(ACA)、基质金属蛋白酶(MMP-9)水平及其与社会功能的相关性。方法选取187例精神分裂症患者,分为DS组(86例)和NDS组(101例),选取体检健康的对照组60名(对照组)。采用阳性和阴性综合征量表(PANSS)评估患者精神状况,住院精神病人社会功能评定量表(SSPI)评估患者社会功能。使用酶联免疫吸附法(ELISA)检测受试者血清ACA、MMP-9水平。分析患者血清ACA、MMP-9水平与临床症状和社会功能的相关性。结果 DS组PANSS总分及阴性症状、一般精神病理量表分均高于NDS组(P <0.05)。三组间血清MMP-9水平比较差异有统计学意义(P <0.05)。进一步两两比较,DS组与NDS组血清MMP-9水平均高于对照组(P <0.05); DS组MMP-9水平高于NDS组(P <0.05)。DS组SSPI总分及因子I、因子II、因子III评分均低于NDS组(P <0.05)。相关分析结果显示,DS组血清MMP-9水平与PANSS一般精神病理量表分、SSPI总分及因子II均呈负相关(P <0.05)。结论 DS患者阴性症状突出,精神症状较难缓解,社会功能受损明显。血清MMP-9水平可能与DS功能预后密切相关。更多还原

【Abstract】 Objective To explore the levels of anti-cardiolipin antibody( ACA),matrix metalloproteinase 9( MMP-9) and their correlations with social function in male patients with deficit schizophrenia( DS) and non-deficit schizophrenia( NDS).Methods A total of 187 patients with schizophrenia were selected and divided into DS group( 86 cases) and NDS group( 101 cases),and 60 healthy controls were selected as control group. They were assessed with Positive and Negative Syndrome Scale( PANSS) and Scale of Social Function in Psychosis Inpatients( SSPI). Serum levels of ACA,MMP-9 were detected through enzyme-linked immunosorbent assay( ELISA). The correlations between serum levels of ACA,MMP-9 and clinical symptoms,social function were analyzed. Results The total score and factor scores of negative symptoms,general psychopathology of PANSS in DS group were significantly higher than those in NDS group( P < 0. 05). There was significant difference in serum levels of MMP-9 among three groups( P < 0. 05). The serum levels of MMP9 of DS and NDS groups were significantly higher than that of control group( P < 0. 05),and the serum level of MMP-9 of DS group was significantly higher than that of NDS group( P< 0. 05). The total score and all factor scores of SSPI in DS group were significantly lower than those in NDS group( P < 0. 05).Correlation analysis showed that the serum level of MMP-9 was negatively correlated with the factor score of general psychopathology of PANSS,as well as total score and factor II score of SSPI in DS group( P < 0. 05). Conclusion DS patients have prominent negative symptoms and obviously impaired social function,and their psychiatric symptoms are difficult to be alleviated. Serum level of MMP-9 may be closely associated with functional prognosis of DS.更多还原