【摘要】 目的评估母乳性黄疸儿童接种乙肝疫苗的安全性。方法采用前瞻性队列研究方法,选择西城区100名母乳性黄疸儿童(经皮测胆黄疸值≥5. 0 mg/d L)和100名健康儿童(对照组)为调查对象,接种乙肝疫苗后观察不良反应情况,比较不良反应发生率。结果接种乙肝疫苗后,黄疸组儿童和对照组儿童总不良反应发生率分别为21. 0%和20. 0%;全身不良反应发生率分别为16. 0%和17. 0%;局部不良反应发生率分别为7. 0%和4. 0%;差异均无统计学意义。两组均未发生严重不良反应。结论母乳性黄疸儿童接种乙肝疫苗具有良好的安全性,建议经皮测胆黄疸值<8 mg/d L、生长发育正常、没有其他禁忌的儿童按时接种乙肝疫苗。更多还原

【Abstract】 Objective To assess the safety in hepatitis B vaccinne for children with breast milk jaundice. Methods According to the method of prospective cohort study,in Xicheng district,100 children with breast milk jaundice( jaundice index of transcutaneous bilirubin measurement,TCB≥5. 0 mg/d L) were enrolled in the jaundice group and 100 healthy children were selected into control group. The adverse reaction rates were compared between the two groups after hepatitis B vaccination.Results The rates of overall adverse reactions of jaundice group and control group were 21. 0% and 20. 0% respectively; the rates of general adverse reactions of the two groups were 16. 0% and 17. 0% respectively; the percentages of local adverse reactions were 7. 0% and 4. 0%,respectively; there was no statistically significant difference between two groups. There was no serious adverse reaction in the two groups. Conclusions Hepatitis B vaccination was safe for the children with breast milk jaundice and was recommended to be carried out on schedule for healthy children with jaundice index of transcutaneous bilirubin measurement lower than 8 mg/d L,proper development and without other contraindications.更多还原