【摘要】 目的:探讨桃红四物汤联合重组人酸性成纤维细胞生长因子(rhaFGF)干预跟骨骨折术后切口愈合的临床疗效。方法:选取跟骨骨折患者60例,按随机数字表法分为治疗组和对照组各30例。治疗组清洁换药后口服桃红四物汤联合外用rhaFGF治疗,对照组清洁换药后仅外用rhaFGF治疗。患者术前、术后1 d、术后14 d抽取空腹血,离心后检测血清碱性成纤维细胞生长因子(bFGF)、角化细胞生长因子(KGF)、血管内皮细胞生长因子(VEGF)含量,并且评估14 d后患者切口平均干燥时间、切口平均愈合时间、术后24 h平均引流量。结果:治疗组切口平均干燥时间、切口愈合时间均低于对照组(P<0.05)。术前,2组bFGF、KGF、VEGF含量比较,差异均无统计学意义(P>0.05)。术后1 d、术后14 d,2组bFGF、KGF、VEGF含量较术前升高(P<0.05),且术后14 d治疗组bFGF、KGF、VEGF含量高于对照组(P<0.05)。结论:桃红四物汤联合rhaFGF对促进皮肤愈合的细胞因子有明显促进作用,可明显促进跟骨骨折术后切口愈合,防止切口并发症发生。更多还原

【Abstract】 Objective: To discuss the clinical effect of Taohong Siwu tang combined with recombinant human Acidic fibroblast growth factor(rhaFGF) in intervening the postoperative incision healing of calcaneal fracture. Methods:Selected 60 cases of patients with calcaneal fracture, and divided them into the treatment group and the control group randomly, 30 cases in each group. After changing dressings,the treatment group received the oral administration of Taohong Siwu tang and the external application of rhaFGR,while the control group received the external application of rhaFGF. Patients received fasting blood extraction before operation,1 and 14 days after operation. After centrifugation,tested the contents of serum basic fibroblast growth factor(bFGF), keratinocyte growth factor(KGF) and vascular endothelial growth factor(VEGF), and elevated the time of incision average drying and the average time of incision healing 14 days later and the average drainage flow twenty-four hours after operation. Results:The average time of incision drying and the average time of incision healing in the treatment group were lower than those in the control group(P<0.05). Before treatment, comparing the contents of bFGF, KGF and VEGF in two groups, there were no significant differences being found(P>0.05). 1 and 14 days after operation,the contents of bFGF,KGF and VEGF in two groups were higher than those before operation(P<0.05). 14 days after operation,the contents of bFGF,KGF and VEGF in the treatment group were higher than those in the control group(P<0.05). Conclusion: The application of Taohong Siwu tang combined with rhaFGF has significant effect in promoting skin healing. It obviously accelerates postoperative incision healing of calcaneal fracture and prevents incision complications.更多还原