【摘要】 目的:调查宜宾市学龄前儿童发生幽门螺杆菌(Hp)感染的情况并分析Hp的耐药性。方法:选择近年来在宜宾市第一人民医院进行Hp检测的622名2～6岁儿童作为研究对象。统计这些儿童Hp感染的发生率,并对发生Hp感染的儿童进行Hp耐药性检测,观察Hp对不同抗生素的耐药性。结果:本研究中622名儿童Hp感染的发生率为21.06%(131/622)。在在131名发生Hp感染的儿童中,男性儿童与女性儿童Hp感染的发生率相比,P>0.05;居住在城市的儿童与居住在农村的儿童Hp感染的发生率相比,P>0.05。在这131名儿童中,年龄为6岁的儿童Hp感染的发生率高于其他年龄段的儿童,P<0.05;年龄为5岁的儿童Hp感染的发生率高于年龄为3～4岁的儿童及年龄为2岁的儿童,P<0.05;年龄为3～4岁的儿童Hp感染的发生率高于年龄为2岁的儿童,P<0.05。从这131名Hp感染儿童的体内随机分离出60株Hp,对这60株Hp进行药敏试验的结果显示,其对替硝唑、克拉霉素、庆大霉素、呋喃唑酮和阿莫西林的耐药率分别为55%、33.3%、21.7%、13.3%和5%。结论:宜宾市学龄前儿童Hp感染的发生率较高,且年龄越大的学龄前儿童Hp感染的发生率越高。Hp对替硝唑和克拉霉素的耐药性较高,对阿莫西林和呋喃唑酮较为敏感。更多还原

【Abstract】 Objective:To investigate the incidence of Helicobacter pylori (Hp) infection in preschool children in Yibin city and analyze the drug resistance of Hp.Methods:A total of 622 children aged 2 ～ 6 years who were tested for Hp in Yibin First People’s Hospital in recent years were selected as the study subjects.The incidence of Hp infection in these children was calculated,and the children with Hp infection were tested for Hp resistance to observe the resistance of Hp to different antibiotics.Results:The incidence of Hp infection was 21.06% (131/622) in 622 children in this study.Among 131 children with Hp infection,the incidence of Hp infection in male children and female children was P > 0.05.The incidence of Hp infection in children living in urban areas was compared with that in rural areas (P > 0.05).Among the 131 children,the incidence of Hp infection in children aged 6 years was higher than that in children of other age groups (P < 0.05).The incidence of Hp infection in children aged 5 years was higher than that in children aged 3 ～ 4 years and 2 years,P < 0.05.The incidence of Hp infection in children aged 3 ～ 4 years was higher than that in children aged 2 years (P < 0.05).Sixty strains of Hp were randomly isolated from 131 children with Hp infection.Drug sensitivity tests of these 60 strains of Hp showed that the drug resistance rates of tinidazole,clarithromycin,gentamicin,furazolidone and amoxicillin were 55%,33.3%,21.7%,13.3% and 5%,respectively.Conclusion:The incidence of Hp infection in preschoolers in Yibin is higher,and the older the preschoolers are,the higher the incidence of Hp infection is.Hp showed higher resistance to tinidazole and clarithromycin and was more sensitive to amoxicillin and furazolidone.更多还原