【摘要】 药物不良反应(adverse drug reactions,ADRs)可分为A型和B型。B型药物不良反应包括免疫介导的药物不良反应(immune I mediated adverse drug reactions,M-ADRs)和非免疫介导药物不良反应。B型药物不良反应与不同人群携带特定人类白细胞抗原(human leukocyte antigen,HLA)等位基因密切相关,除传统方法用于检测ADR以外,新一代TCR测序、单细胞测序及肠道菌群检测等方法可用于预测药物不良反应。本文主要综述目前B型药物不良反应的发病机制、遗传因素以及临床应用的进展,有助于预防以及更好地管理药物不良反应。更多还原

【Abstract】 Adverse drug reactions(ADRs) can be classified into pharmacological on-target(Type A ADRs) and off-target(Type B ADRs) type. Type B ADRs include immune mediated ADRs(IM-ADRs) and non-immune mediated ADRs,which are strongly linked to specific HLA alleles. New generation of TCR sequencing technique has emerged as an experimental approach to investigate immunologic mechanisms as well as biomarkers of ADRs. There is growing interest in the role of human microbiome and single cell sequencing in predicting drug response. The immunogenetics and pathogenesis of Type B ADRs was reviewed in this article,for further understanding of pathogenesis and forming the basis of pre-drug screening strategies.更多还原