【摘要】 目的:探讨结核杆菌T细胞斑点实验(T-SPOT.TB)对有呼吸系统症状且疑似伴发活动性肺结核患者诊断准确性的影响因素。方法:回顾性分析2019年2月至2020年7月来我院就诊的89例有呼吸系统症状且疑似伴发活动性肺结核患者的临床资料、临床诊断结果、T-SPOT.检查、血球、生化检查、影像学诊断结果;分析T-SPOT.TB对活动性肺结核的诊断效能,并应用Logistic回归方法分析T-SPOT.TB检查假阳、假阴结果产生的相关因素。结果:T-SPOT.TB诊断活动性肺结核的灵敏度、特异度、阳性预测值、阴性预测值分别为87.75%、60.00%、72.89%、80.00%;T-SPOT.TB假阳性患者BMI、前白蛋白、淋巴细胞计数、淋巴单核比的均值大于真阳性+真阴性患者(P<0.05);T-SPOT.TB假阴性患者淋巴细胞计数、白蛋白均值小于真阳性+真阴性患者,差异有统计学意义(P<0.05);Logistic回归分析显示,BMI (OR=1.472,P=0.03)为产生假阳性的危险因素。结论:BMI是T-SPOT.TB诊断假阳性的危险因素。更多还原

【Abstract】 Objective:To investigate the influencing factors of the tuberculosis T cell spot test(T-SPOT.TB) on the diagnostic accuracy of patients with respiratory symptoms and suspected of active pulmonary tuberculosis.Methods:Retrospective analysis of the clinical data,clinical diagnosis results,T-SPOT examination,blood cell,biochemical examination,and clinical data of 89 patients with respiratory symptoms and suspected of active pulmonary tuberculosis in our hospital from February 2019 to July 2020 were retrospectively analyzed.Imaging diagnosis results.Analyze the diagnostic efficacy of T-SPOT.TB for active pulmonary tuberculosis,and use Logistic regression method to analyze the related factors of false positive and false negative results of T-SPOT.TB.Results:The sensitivity,specificity,positive predictive value,and negative predictive value of T-SPOT.TB in the diagnosis of active pulmonary tuberculosis were 87.75%,60.00%,72.89%,and 80.00% respectively.T-SPOT.TB false positive patients with BMI and prealbumin The mean values of lymphocyte count and lymphatic mononuclear ratio are greater than those of true positive and ten true negative patients(P<0.05).The mean lymphocyte count and albumin of T-SPOT.TB false negative patients are less than those of true positive and ten true negative patients,and the difference is statistically significant Scientific significance(P <0.05).Logistic regression analysis showed that BMI(OR=1.472,P=0.03) among the related factors that produced false positive results was the risk factor for false positive results.Conclusion:BMI is a risk factor for false positive diagnosis of T-SPOT.TB.更多还原