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TNF-α拮抗剂治疗复发性疱疹样脓疱病一例

Recurrent impetigo herpetiformis treated with TNF-α antagonist: a case report

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【作者】 王娟娟苏玉华丁瑜洁冷红季江施辛

【Author】 WANG Juanjuan;SU Yuhua;DING Yujie;LENG Hong;JI Jiang;SHI Xin;Department of Dermatology,the Second Affiliated Hospital of Soochow University;

【通讯作者】 季江;

【机构】 苏州大学附属第二医院皮肤科

【摘要】 患者,女,31岁。妊娠期反复脓疱加重1个月。患者8年前妊娠期曾全身出现红斑、脓疱,产后皮损自行消失。根据患者既往病史、症状、体征及辅助检查,诊断"疱疹样脓疱病",入院后予TNF-α拮抗剂皮下注射,辅以复方甘草酸苷、阿奇霉素抗炎及外用药治疗,1周后患者皮疹明显好转出院。

【Abstract】 A 31-years-old female patient presented with widespread erythema and pustules during pregnancy, aggravating for 1 month. The patient had a history of the similar symptoms during pregnancy before 8 years ago and the lesions disappeared spontaneously after delivery. According to the patient’s previous medical history, symptoms, physical signs and laboratory examination, the diagnosis of "impetigo herpetiformis" was made. The patient was injected subcutaneously with TNF-α antagonist, supplemented with Minol, Azithromycin anti-inflammatory and topical medication. The lesion was significantly improved after one week treatment.

【关键词】 疱疹样脓疱病TNF-α拮抗剂
【Key words】 impetigo herpetiformisTNF-α antagonist
【基金】 国自然青年科学基金项目(编号:81803127);苏州市民生科技项目(编号:SS201643);苏州市科技发展计划(编号:SYS2018056)
  • 【文献出处】 中国麻风皮肤病杂志 ,China Journal of Leprosy and Skin Diseases , 编辑部邮箱 ,2020年03期
  • 【分类号】R758.66
  • 【下载频次】109
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