【摘要】 目的观察不同剂量布洛芬治疗早产儿动脉导管未闭(PDA)的疗效及安全性。方法收集2019年9月1日～2020年8月30日收治的98例胎龄<37周且体质量<2500g的PDA患儿,随机分为高剂量治疗组(n=49)和低剂量治疗组(n=49)。高剂量组患儿给予口服或管饲布洛芬混悬液首剂20mg/kg,24h、48h后各给予布洛芬混悬液10mg/kg;低剂量组:首剂10mg/kg,24h、48h后各给予布洛芬混悬液5mg/kg。第一疗程完成72h后动脉导管仍未关闭者给予第二疗程治疗,剂量及方法同第一疗程。超声心动图记录,观察两组患儿治疗后动脉导管关闭情况及不良反应发生率。结果布洛芬治疗第一疗程结束以后,高剂量组动脉导管关闭率为69.4%,低剂量组动脉导管关闭率为46.9%,差异有统计学意义(P<0.05),第二疗程,高剂量组与低剂量组相比,差异无统计学意义(P>0.05),两个疗程结束后,高剂量组总成功率与低剂量组相比,差异有统计学意义(P<0.05),治疗期间,不良反应发生率差异无统计学意义(P>0.05)。结论高剂量布洛芬治疗早产儿动脉导管未闭效果显著,消化道出血、支气管肺发育不良等不良反应无增加。更多还原

【Abstract】 Objective To investigate the efficacy and safety of different doses of ibuprofen in the treatment of patent ductus arteriosus in premature infants.Methods To collect 98 PDA children with gestational age <37 weeks and body mass <2500 g from September 01,2019 to August 30,2020,were randomly divided into high-dose treatment group(n=49) and low-dose treatment group(n=49).Children in the high-dose group were given the first dose of 20 mg/kg of ibuprofen suspension orally or by gavage,and 10 mg/kg of the ibuprofen suspension after 24 h and 48 h;the low-dose group:the first dose of 10 mg/kg,24 h,After 48 hours,they were given ibuprofen suspension 5 mg/kg.Patients who had not closed the arterial catheter 72 hours after the completion of the first course of treatment were given a second course of treatment with the same dosage and method as the first course of treatment.Echocardiographic records were performed to observe the closure of the arterial duct and the incidence of adverse reactions after treatment in the two groups.Results After the first course of ibuprofen treatment,the closing rate of the arterial catheter in the high-dose group was 69.4%,and the closing rate of the arterial catheter in the low-dose group was 46.9%.The difference was significant(P<0.05).In the second course of treatment,there was no significant difference between the high-dose group and the low-dose group(P>0.05).After the two courses of treatment,the total success rate of the high-dose group was significantly different from that of the low-dose group(P<0.05).During treatment,there was no significant difference in the incidence of adverse reactions(P>0.05).Conclusion High-dose ibuprofen is effective in treating patent ductus arteriosus in premature infants,and there is no increase in adverse reactions such as gastrointestinal bleeding and bronchopulmonary dysplasia.更多还原