【摘要】 目的 探讨5例儿童感染2019新型冠状病毒的临床特征。方法 回顾性分析2020年2月在宁波市感染新型冠状病毒儿童的临床及流行病学特征。结果 (1) 5例患儿均属于家庭聚集性发病。(2) 5例患儿中仅1例出现鼻塞、流涕(20%),其余均属无症状感染者(80%),未出现消化道症状和神经系统症状。(3)患儿外周血一般表现为淋巴细胞计数增高(1/5),天冬氨酸氨基转移酶(AST)增高(1/5),血肌酸激酶MB同工酶(CKMB)增高(1/5),纤维蛋白原降低(FIB)(2/5);白细胞计数、C反应蛋白(CRP)、降钙素原、总蛋白(TB)、谷丙氨酸氨基转移酶(AST)、血清肌钙蛋白Ⅰ(CTNI)、肌酸激酶(CK)、血肌酐(SCr)和D-二聚体(D-D)等指标无明显变化。(4)鼻口咽拭子标本经RT-PCT检测核酸阳性平均排毒时间16d (7～22d),5例患儿连续2次咽拭子转阴,同期的粪便仍可检出2019-nCoV核酸。(5) 5例患儿入院后多次行肺部影像学检查(胸部DR、胸部CT)均未见明显改变。结论 儿童感染新型冠状病毒的临床表现可无特异性,相关症状较成人轻。家庭聚集性发病及输入性病例为儿童主要感染途径。更多还原

【Abstract】 Objective To characterize the clinical characteristics of 5 children infected with the COVID-19.Methods Retrospective analysis of clinical manifestations,laboratory,imaging data and epidemiological history of children infected with the COVID-19 in Ningbo in February 2020.Results(1) All 5 cases of children were family clustered.(2) Nasal congestion and runny nose occurred in only 1 of the 5 patients(20%),and the rest were asymptomatic(80%),and no gastrointestinal or neurological symptoms were found.(3) Peripheral blood of children generally showed the high level of LYM(1/5),high level of AST(1/5),high level of CKMB(1/5),low level of FIB decreased(2/5),and the WBC,CRP,PCT,TB,AST,CTNI,CK,SCr and DD dimers had no significant changes.(4) The nucleic acids of asopharyngeal swab specimens had an average detoxification time of 16 d(7 d-22 d) with RT-PCT detection.5 children with pharyngeal swabs turned negative twice in a row,but the fecal specimens can still detect COVID-19 nucleic acid at the same period.(5) 5 patients underwent multiple pulmonary imaging examinations(DR and CT) after admission,and no significant changes were seen.Conclusion The clinical manifestations of novel coronavirus infection in children are not specific,and the symptoms are less than adults.The main way of infection in children is family aggregation and imported cases.更多还原