【摘要】 目的:分析冠状动脉粥样硬化性心脏病(CAD)和慢性阻塞性肺疾病(COPD)患者血清中超氧化物歧化酶(SOD)活性和丙二醛(MDA)浓度,评估CAD和COPD患者体内氧化应激状态的变化差异,探讨这2个指标在临床的应用价值。方法:收集49例健康体检者、66例确诊为COPD和65例确诊为CAD患者的血清标本,测量其SOD活性;收集41例健康体检者、50例确诊为COPD和86例确诊为CAD患者的血清标本,测量其MDA浓度,进行统计学分析。结果:与健康对照相比,CAD和COPD患者血清中SOD活性均显著降低,差异有统计学意义(P<0.05)。与健康对照相比,CAD患者血清中MDA浓度略下降,差异无统计学意义(P=0.228 7),COPD患者血清中MDA浓度显著升高,差异有统计学意义(P<0.05)。结论:在老年慢性心肺疾病患者血清中均存在氧化应激的异常变化,COPD患者血清氧化应激紊乱更突出。建议以SOD活性作为CAD的预警指标,而SOD和MDA浓度均可以作为COPD的预警指标。从ROC曲线下面积来看,SOD作为COPD的预警指标更好。更多还原

【Abstract】 Objective:To evaluate the status of oxidative stress in patients with coronary artery heart disease(CAD)and chronic obstructive pulmonary disease(COPD),detect serum superoxide dismutase(SOD)activity and malondialdehyde(MDA)concentrations,and explore the clinical values of these two indicators. Method:Serum samples were collected from 49 healthy subjects,66 patients diagnosed with COPD and 65 patients diagnosed with CAD,and their SOD activity was measured.Serum samples were collected from 41 healthy subjects,50 patients diagnosed with COPD,and 86 patients diagnosed with CAD,and their MDA concentrations were measured.Statistical analysis was performed using SPSS. Result:Compared with healthy controls,serum SOD activity was significantly lower in patients with CAD and COPD,the difference was statistically significant(P<0.05);compared with the control group,serum MDA concentration in patients with CAD decreased slightly,the difference was not statistically significant(P=0.228 7).Serum MDA concentration in patients with COPD was significantly increased and the difference was statistically significant(P<0.05).Conclusion:There is an abnormality of oxidative stress in serum of the patients with chronic cardiopulmonary disease.There is a dominant oxidative stress disorder in serum of the patients with COPD disease.We recommend SOD activity as a prediction index of CAD,while SOD and MDA concentrations both as prediction indexes of COPD.SOD could be used as a valuable prediction marker for COPD based on the ROC curve.更多还原