【摘要】 目的采用Meta分析法系统评估补充n-3多不饱和脂肪酸(n-3 PUFAs)对糖尿病患者肾功能指标的影响,为糖尿病慢病管理提供理论依据。方法全面检索数据库,包括Pubmed、Cochrane Library、Embase及中国知网、万方、维普数据库。文献检索起止时间均从建库至2018年8月31日,收集糖尿病患者口服n-3 PUFAs的随机对照试验,评价文献质量,提取有效数据后,采用RevMan 5.3软件进行数据分析。结果共纳入11项RCT研究,614名研究对象。Meta分析显示,与对照组相比,补充n-3 PUFAs可降低糖尿病患者尿白蛋白排泄[MD=-2.65,95%CI(-4.67,-0.62),P=0.01]和血肌酐水平[MD=-2.60,95%CI(-4.98,-0.22),P=0.03],并延缓肌酐清除率下降[MD=9.23,95%CI(4.37,14.09),P=0.0002]。但两组糖尿病患者的尿素氮、尿酸及肾小球滤过率差异均无统计学意义(P>0.05)。结论 n-3 PUFAs可降低糖尿病患者的尿白蛋白排泄和血肌酐水平,延缓肌酐清除率下降,但对尿素氮、尿酸及肾小球滤过率均无显著改善。更多还原

【Abstract】 Objective We performed a meta-analysis to systematically evaluate the impact of n-3 polyunsaturated fatty acids(n-3 PUFAs)supplementation on renal functions in diabetes patients,and to provide theoretical basis for chronic diabetic disease management.Methods We searched Pubmed,Cochrane Library,Embase,and three major Chinese biomedical databases(CNKI,VIP and WANGFANG)for randomized controlled trials(RCTs)to examine the effects of n-3 PUFAs on renal function in diabetes patients,published before August 31,2018.Quality assessment and data extraction were performed,and RevMan 5.3 software was used for the Meta-analysis.Results We included 11 RCTs representing 614 patients with diabetes in this meta-analysis.The meta-analysis showed that,n-3 PUFAs supplementation significantly reduced urinary albumin excretion[MD=-2.65,95% CI(-4.67,-0.62),P=0.01]and serum creatinine level[MD=-2.60,95% CI(-4.98,-0.22),P=0.03],and delayed creatinine clearance decrease[MD=9.23,95% CI(4.37,14.09),P=0.0002].However,n-3 PUFAs supplementation failed to decrease urea nitrogen,uric acid and glomerular filtration rate.Conclusions In diabetes patients,n-3 PUFAs supplementation provides beneficial effects on urinary albumin excretion,serum creatinine and creatinine clearance,but has no obvious improvement effects on urea nitrogen,uric acid and glomerular filtration rate.更多还原