【摘要】 目的:探讨血清巨泌乳素(MPRL)水平检测在抗精神病药致高泌乳素血症(HPRL)中的临床意义。方法:于2016年4月至2018年4月共收集精神分裂症患者133例,对其进行利培酮或氨磺必利单药治疗6周,于治疗前、治疗2周、治疗4周和治疗6周后检测总泌乳素(T-PRL)和MPRL水平。结果:经治疗2周后有75. 09%(100/133)的患者达到HPRL诊断标准,其中43%(43/100)符合MPRL血症诊断标准;且血清MPRL与T-PRL水平呈正相关。结论:利培酮、氨磺必利所致HPRL患者中有近一半实为MPRL血症。MPRL检测值得引起临床关注。更多还原

【Abstract】 Objective: To investigate the situation and clinical significance of macroprolactin in patients with hyperprolactinemia induced by antipsychotics. Method: 133 patients with schizophrenia were treated with risperidone or amisulpride alone for 6 weeks from April 2016 to April 2018. The levels of T-PRL and MPRL were measured before the treatment,and after 2,4,6 weeks of the treatment. Results: After 2 weeks of the treatment,75. 09%( 100/133) of the patients met the diagnostic criteria of hyperprolactinemia,the incidence of macroprolactinemia was 43%( 43/100). The MPRL level was positively correlated with T-PRL level.Conclusion: Nearly half of the patients with hyperprolactinemia caused by risperidone and amisulpride are macroprolactinemia. The detection of macroprolactin should be paid attention in clinical practice.更多还原