【摘要】 目的:探讨中国黑龙江地区汉族人群FK506结合蛋白5(FKBP5)基因多态性与精神分裂症的关系。方法:采用SNaPshot测序法检测和分析49例汉族精神分裂症患者(患者组)和49名汉族健康对照者(对照组)的FKBP5基因rs3800373、rs1360780、rs9296158和rs9470080位点基因型和等位基因频率。结果:FKBP5 rs3800373位点基因型频率两组间差异有统计学意义(P<0.05); Logistic回归分析显示,FKBP5基因rs3800373位点TT基因型携带者精神分裂症发生风险明显高于GT基因型携带者(95%CI:0.117～0.756,P=0.01)。结论:FKBP5基因rs3800373位点基因多态性可能与中国黑龙江地区汉族人群精神分裂症发病风险有关。更多还原

【Abstract】 Objective: To investigate the relationship between FK506 binding protein 5(FKBP5) gene polymorphism and schizophrenia in Han people in Heilongjiang province,China. Method:The genotypes and allele frequencies of FKBP5 genes at rs3800373,rs1360780,rs9296158 and rs9470080 were detected by SNaPshot sequencing in 49 Han Chinese schizophrenics(th-e patient group) and 49 Han healthy controls(the control group). Results:The genotype frequency of FKBP5 rs3800373 was significantly different between the two groups(P<0.05).Logistic regression analysis showed that the risk of schizophrenia in TT genotype carriers with rs3800373 of FKBP5 gene was significantly higher than that of GT genotype carriers(95%CI:0.117-0.756,P=0.01). Conclusion:The polymorphism of FKBP5 gene rs3800373 may be related to the risk of schizophrenia in the Han population in Heilongjiang,China.更多还原