【摘要】 目的:将浓缩生长因子(CGF)与Bio-oss以不同比例混合,探讨何种比例可以达到更佳的位点保存效果。方法:24只雄性新西兰兔下颌双侧第一前臼齿拔牙窝,左侧于右侧手术8周后进行。A、B、C组为CGF与Bio-oss以2:1,1:1,1:2比例混合,D组为空白对照。观察4周、12周新骨形成比例及骨成熟程度,X线片计算牙槽骨吸收量。结果:同一时间点,新骨形成量A>B>C>D (P<0.05),A、B、C组牙槽骨吸收量均小于D组(P<0.05)。同一组别,12周时新生骨量、骨成熟程度及牙槽骨吸收量均高于4周时(P<0.05)。结论:CGF与Bio-oss以2:1比例混合时位点保存效果更佳。更多还原

【Abstract】 Objective: Different ratios of CGF and Bio-oss were filled in teeth extraction socket, to explore the ratio of better site preservation effect. Methods: 24 male New Zealand rabbits, the experiment has been approved by the ethics committee of Hospital of Stomatology Hebei Medical University. Groups A,B and C were CGF mixed with Bio-oss at the ratio of 2:1, 1:1 and 1:2. Group D was control group. The teeth extraction socket of the first premolar on both sides of mandible was filled with the same ratio.The left operation was performed on 8 weeks after the right operation, and then they were sacrificed after 4 weeks. Amount of new bone formation and the degree of bone maturity were observed histologically at 4 and 12 weeks using HE and Masson stain. X-rays were used to evaluate the alveolar bone absorption.All images were analyzed by image-pro Plus6.0. Results: At the same time, the order of was group A, B, C and D(P<0.05), alveolar bone resorption in group A, B and C was smaller than group D(P<0.05). At the same group, the new bone formation, bone mass, alveolar bone resorption at 12 weeks was higher than that at 4 week(P<0.05). Conclusion: When CGF and Bio-oss were mixed in the ratio of 2:1 was better.更多还原