【摘要】 生物钟是生物适应环境周期性变化的一种内在机制,是体内无形的"钟表"。生物钟对机体健康有着不可或缺的积极作用,生物钟表达紊乱导致一系列相关疾病的发生和发展,严重影响机体健康或生存。近年来大量的研究发现,生物钟基因的改变可引起脂肪组织功能的改变。分析表明,外界因素通过影响生物钟节律的表达,从而影响脂肪组织的蛋白质组和功能振荡。该文就时钟蛋白及其关键信号通路在白色、棕色和米色脂肪组织中的功能作用及影响进行综述。更多还原

【Abstract】 The circadian clock is an internal adaptation mechanism to the periodic changes of the environment,and is an invisible "clock" in the body. The clock genes regulate multiple physiological responses,while the disorder of their expression causes the occurrence and development of a series of diseases. In recent years,a large number of studies have revealed the regulatory role of the circadian clock in adipose tissue. In response to the stimuli,functional disturbance of adipose tissue can be induced via modulating the expression of the circadian clock gens. Here,we summarize the functions and effects of clock proteins in regulating the metabolism function of white,brown,and beige adipose tissues.更多还原