【摘要】 SIRT7是哺乳动物组蛋白去乙酰化酶Sirtuins家族成员,是高度保守的NAD+依赖的蛋白质去乙酰化酶,调控细胞中多种蛋白的乙酰化水平,参与许多重要的生命活动,如蛋白质合成、代谢、细胞应激、炎症、衰老和肿瘤.在过去的几年里,人们对它的认识有质的飞跃,本文主要对SIRT7的特点、功能和调节机制进行回顾和总结,以期为进一步研究提供参考.更多还原

【Abstract】 SIRT7, a member of the mammalian Sirtuins family, is a highly conserved NAD+dependent protein deacetylase, which regulates the acetylation level of various proteins in cells, thus regulating many important cellular processes such as protein synthesis, metabolism,cell stress, inflammation, aging and tumors. The past few years has seen significant progress in our knowledge about SIRT7. Here, we review recent advances in the characteristics, functions and regulation mechanisms of SIRT7, providing useful information for further research.更多还原