【摘要】 内酯化合物在医药、高分子等领域都有重要的应用.其中ε-己内酯是生物可降解材料聚己内酯(poly(ε-caprolactone))的单体以及聚酯的改性剂,目前年产量近10万吨,未来前景广阔.本文主要介绍了本课题组在分子氧氧化法合成内酯化合物特别是ε-己内酯方面所做的工作,以及国内外关于内酯化合物合成的研究进展以及展望.本课题组在传统的Baeyer-Villiger氧化环酮化合物制备内酯产物的研究基础上加以改进,分别从环己酮、K/A油(环己酮和环己醇的混合物)、环己烷出发,以氧气为氧化剂,一步反应得到ε-己内酯,较传统Baeyer-Villiger氧化法更加简单、高效、绿色环保,具有潜在的工业发展前景.更多还原

【Abstract】 Lactones are widely applied in the fields of pharmacy and polymer. Among them, ε-caprolactam is the monomer of biodegradable poly-caprolactone and also usually used as the modifier of polyester, which almost owns the capacity of 100,000 ton/year. Its demand would grow rapidly with the increasingly strict requirement in environmental protection. In this review, the progress on the aerobic synthesis of caprolactone and the further study on the oxidant modification and new path were mainly discussed. Our group focused on the one-pot transformation of cyclohexanone K/A oil and cyclohexane to ε-caprolactam, respectively, which would be more efficient and environmentally friendly methods and own potential prospect of the industrial application.更多还原