【摘要】 目的 构建乳腺癌相关淋巴水肿的风险评分系统。方法 本横断面研究于2017年4月至2018年12月共纳入533例乳腺癌术后患者。首先根据单因素分析筛选乳腺癌相关淋巴水肿的危险因素,再根据多因素Logistic回归分析结果中的优势比构建乳腺癌相关淋巴水肿的评分系统。结果 本研究中乳腺癌相关淋巴水肿的评分系统分值为6～22分;受试者工作特征曲线下面积为0.736(95%CI=0.662～0.811);当其评分为15.5分时敏感度和特异度最佳,分别为83.3%%和57.3%;Hosmer-Lemeshow拟合优度检验结果为χ~2=5.134(P=0.274)。结论 本研究中评分系统的预测效能和准确度均可接受,可用于预测乳腺癌术后淋巴水肿风险,从而筛查出高危人群。更多还原

【Abstract】 Objective: We aimed to establish a scoring system to predict the risk of breast cancer-related lymphedema.Methods: From April 2017 to December 2018, 533 patients who previously underwent surgery for breast cancer were enrolled in this cross-sectional study. Univariate analysis was performed to explore and define the risk factors. A scoring system was then established on the basis of odds ratio values in the regression analysis.Results: The additive scoring system values ranged from 6 to 22. The receiver operating characteristic(ROC) curve of this scoring system showed a sensitivity and specificity of 83.3% and 57.3%, respectively, to predict the risk of lymphedema at a cut-off of 15.5 points; the area under the curve was 0.736(95%confidence interval: 0.662—0.811), with χ~2= 5.134(P = 0.274) for the Hosmer—Lemeshow test.Conclusions: The predictive efficiency and accuracy of the scoring system were acceptable, and the system could be used to predict and screen groups at high risk for breast cancer-related lymphedema.更多还原