【摘要】 通过共沉淀-模板法制备SiO₂-CaO-P₂O₅-CoFe₂O₄磁性空心微球.采用综合热分析（TG-DTA）、X射线粉末衍射（XRD）、扫描电子显微镜（SEM）和X射线能谱（EDS）系统研究不同玻璃组成对玻璃陶瓷空心微球形貌和结晶的影响.制备的玻璃微球经过800℃热处理2 h后,可以得到玻璃陶瓷空心微球,其平均粒径为300 nm左右,且获得的微球存在一定团聚现象.同时在微球玻璃中析出纯的磁性CoFe₂O₄晶体相.利用茶碱作为药物模型,研究玻璃陶瓷空心微球的药物缓释行为,发现这种磁性玻璃陶瓷空心微球兼具靶向、磁热疗、生物相容性、药物缓释于一体,在肿瘤治疗方面有重要应用.更多还原

【Abstract】 The SiO₂-CaO-P₂O₅-CoFe₂O₄ magnetic hollow microspheres were prepared by a template mediated co-precipitate method. The impact of the contents on the morphology and crystallization of the glass ceramic microsphere were studied by means of integrated thermal gravimetric analyzer（TG-DTA）, X-ray powder diffraction（XRD）, scanning electron microscope（SEM） and X-ray energy dispersive spectrum（EDS）. After annealed at 800 ℃ for 2 h, the hollow microspheres with mean size of 300 nm was obtained. Some degree of aggregation between the microspheres was observed in SEM images. Moreover, pure CoFe₂O₄ nanocrystals were precipitated from the glassy matrix after heat treatment. The obtained hollow glass-ceramic microspheres exhibited sustained drug release behavior by using TP as drug model. The hollow glass-ceramic microspheres developed in this study combine multi-functions of magnetic targeting, hyperthermal treatment, biocompability and drug delivery, and they have great potential applications in tumor therapy.更多还原