【摘要】 目的探讨非动脉炎性前部缺血性视神经病变(non-arteritic anterior ischemic optic neuropathy,NAION)患者的危险因素及中医证型的相关性研究。方法纳入2009年至2019年间北京中医药大学东方医院诊断为NAION的167例患者,分析年龄、高脂血症、高血压、糖尿病、脑梗死、冠心病、外周动脉硬化对气虚血瘀证、气滞血瘀证、肝肾阴虚证、气血两虚证分布的影响,并进行统计分析。结果 (1) NAION患者气虚血瘀证、气滞血瘀证、肝肾阴虚证、气血两虚证之间视力、视网膜神经纤维层(retinal nerve fiber layer,RNFL)厚度、平均缺损(mean deviation,MD)、平均光敏感度(mean sensitivity,MS)比较无统计学差异(P>0.05),不同病程的患者视力、MD、MS比较无统计学差异,RNFL比较有显著统计学差异(P<0.01);(2) 50岁及以下与50岁以上人群中医证型构成比有显著统计学差异(P<0.01);(3) 50岁及以下与50岁以上人群高脂血症、高血压病的患病人数比较有显著统计学差异(P<0.01),糖尿病、脑梗死、冠心病、外周动脉硬化患病人数比较无统计学差异(P>0.05);(4) NAION患者有无高脂血症、高血压、糖尿病、脑梗死、冠心病、外周动脉硬化病史在不同证型的分布上存在统计学差异(P<0.05)。结论 NAION患者伴有的不同危险因素与中医证型的分布有一定的相关性。更多还原

【Abstract】 Objective To investigate the correlation between risk factors and traditional Chinese medicine( TCM) syndromes in patients with non-arteritic anterior ischemic optic neuropathy( NAION).Methods A total of 167 patients diagnosed as NAION in the Dongfang Hospital of Beijing University of Chinese Medicine from 2009 to 2019 were included. The effects of age,hyperlipidemia,hypertension,diabetes,cerebral infarction, coronary heart disease, peripheral arteriosclerosis on the distribution of syndrome of qi deficiency and blood stasis,syndrome of qi stagnation and blood stasis,syndrome of yin deficiency of both liver and kidney and syndrome of deficiency both qi and blood,were counted and statistical analyzed. Results( 1) There was no significant difference in vision,the thickness of retinal nerve fiber layer( RNFL),mean deviation( MD),mean sensitivity( MS) between syndrome of qi deficiency and blood stasis,syndrome of qi stagnation and blood stasis,syndrome of yin deficiency both liver and kidney,and syndrome of deficiency both qi and blood in NAION patients( P>0.05). There were no statistically significant differences in vision,MD and MS among patients with different disease courses,while there were statistically significant differences in RNFL( P<0.01).( 2) There was significant statistical difference in the proportion of TCM syndrome types between the ages under 50 and over 50( P<0.01).( 3) There was a significant statistical difference in the number of patients with hyperlipidemia and hypertension between the ages under 50 and over 50( P<0.01). There was no statistical difference in the number of patients with diabetes,cerebral infarction,coronary heart disease and peripheral arteriosclerosis between the ages under 50 and over 50( P>0.05).( 4) There were statistical differences in the distribution of different syndrome types in the history of NAION patients with or without hyperlipidemia,hypertension,diabetes,cerebral infarction,coronary heart disease,and peripheral arteriosclerosis( P<0.05). Conclusion NAION patients with different risk factors have a certain correlation with the distribution of TCM syndromes.更多还原