【摘要】 目的以血清学检测结果了解郑州市初次无偿献血者丙型肝炎的流行情况,为制定丙型肝炎防治对策提供依据。方法对2016—2018年无偿献血者,进行2遍不同厂家酶联免疫吸附试验(ELISA)进行检测,两种试剂检测均为阳性或者一阴一阳判抗-丙型肝炎病毒(HCV)为阳性,反之为阴性。应用唐山启奥Shinow 9.0软件统计初次和多次献血者抗-HCV检测结果,然后对初次献血者按性别、年龄、职业、学历、民族进行统计分析。结果献血总人数为648 049人,其中抗-HCV总阳性人数为0.28%(1 794/648 049),初次献血者抗-HCV阳性率为0.45%(1 478/328 753),多次献血抗-HCV阳性率为0.09%(316/319 296),初次和多次献血抗-HCV阳性率比较,差异有统计学意义(P<0.01)。初次献血者抗-HCV阳性率如下:男性占0.45%(907/199 369),女性占0.44%(571/129 384),差异无统计学意义(P>0.05);男女间抗-HCV阳性率均随年龄增加而增长,18～25岁男女最低分别为0.30%和0.29%,46～55岁男女最高分别为1.06%和1.31%,男性年龄间和女性年龄间比较,差异均有统计学意义(P<0.01);农民最高占0.75%(110/14 743),学生最低占0.28%(385/135 710),不同职业间比较差异有统计学意义(P<0.01);小学文化程度最高占1.04%(5/482),本科最低占0.31%(295/93 954),不同文化程度间比较差异有统计学意义(P<0.05);维吾尔族最高占0.89%,蒙古族最低占0.28%,不同民族间比较差异无统计学意义(P>0.05)。结论郑州市初次无偿献血者丙型肝炎属于低流行状态,其感染与年龄、职业以及文化程度有关,与性别和民族无关,应加强丙型肝炎传播途径的知识宣传和防治工作。更多还原

【Abstract】 Objective To investigate the prevalence of Hepatitis C among the first-time unpaid blood donors in Zhengzhou by serological detection, and to provide a basis for the prevention and treatment of Hepatitis C.Methods Free blood donors from 2016 to 2018 were tested twice by ELISA from different manufacturers. Anti-HCV was judged positive when one or both two reagents were positive, otherwise negative. Tangshan Qi’ao 9.0 software was used to calculate the anti-HCV test results of the first-time and repeated blood donors. Then the first-time blood donors were statistically analyzed by gender, age, occupation, educational background, and ethnic group.Results The total number of blood donors was 648 049, among which the total number of anti-HCV positive was 0.28%(1 794/648 049), the positive rate of anti-HCV of first-time blood donors was 0.45%(1 478/328 753), and the positive rate of anti-HCV of repeated blood donors was 0.09%(316/319 296). The difference had significance of statistics(P<0.01). In this study, the positive rate of anti-HCV of first-time blood donors was as follows: 0.45%(907/199 369) for males and 0.44%(571/129 384) for females, there was no statistical significance(P>0.05). The positive rate of anti-HCV increased with age for both male and female, the lowest for both male and female aged 18-25 years was 0.30% and 0.29%, respectively; and the highest for both male and female aged 46-55 years was 1.06% and 1.31%, respectively. There was a significant difference between male and female age groups(P<0.01). There were significant differences among different occupations(P<0.01), among which the highest was 0.75%(110/14 743) for farmers and the lowest was 0.28%(385/135 710) for students. There were significant differences among different educational levels(P<0.05), among which the educational level of primary school was the highest at 1.04%(5/482) and that of undergraduate was the lowest at 0.31%(295/93 954). There was no difference among different nationalities(P>0.05), but the Uygur nationality was the highest and the Mongolian nationality was the lowest.Conclusion The infection of Hepatitis C among the first-time unpaid blood donors in Zhengzhou is related to age, occupation, and education level, but has nothing to do with gender and nationality.更多还原