【摘要】 目的探讨芬吗通雌激素预处理治疗多囊卵巢综合征（PCOS）不孕患者的效果。方法选取2017年6月至2019年3月于广东省计划生育专科医院妇科门诊治疗的60例PCOS不孕的薄型子宫内膜患者。按随机数表法将患者分为补佳乐组和芬吗通组,每组30例。给予补佳乐组患者补佳乐预处理,给予芬吗通组患者芬吗通雌激素预处理。所有患者接受3个月经周期的雌激素预处理后,接受促排卵治疗。比较两组用药前后卵泡刺激素（FSH）、黄体生成素（LH）、雌二醇（E₂）、雄激素（T）、抗苗勒管激素（AMH）、窦卵泡数（AFC）、子宫内膜厚度（EMT）及卵巢动脉收缩期峰值流速（PSV）。随访促排卵妊娠情况。结果两组用药后FSH、LH、T、AMH、AFC分别与同组用药前比较,差异无统计学意义（均P>0.05）。用药后,两组E₂水平高于用药前,EMT和PSV值均大于用药前（均P<0.05）。芬吗通组用药后FSH、LH、T、AMH水平及AFC分别与补佳乐组比较,差异无统计学意义（均P>0.05）。芬吗通组用药后E₂水平高于补佳乐组,EMT和PSV值均大于补佳乐组（均P<0.05）。芬吗通组妊娠率[53.3%（16/30）]高于补佳乐组[26.7%（8/30）]（P<0.05）。结论经阴道使用芬吗通雌激素是增加PCOS不孕的薄型子宫内膜患者EMT的一种有效的预处理用药方案,有助于升高患者血清雌激素水平,加上促排卵治疗有利于改善妊娠结局。更多还原

【Abstract】 Objective To investigate therapeutic effect of pretreatment of femoston on polycystic ovary syndrome（PCOS） infertility.Methods A total of 60 infertile patients with PCOS and thin endometrium were selected in Department of Gynecology in Provincial Special Hospital of Family Planning in Guangdong from June 2017 to March 2019. The patients were divided into progynova group and femoston group according to random number table method, with 30 cases in each group. The patients in progynova group were given progynov pretreatment and the patients in femoston group were given femoston pretreatment. All patients received ovulation induction therapy after estrogen pretreatment for 3 menstrual cycles. Follicle stimulating hormone（FSH）, luteinizing hormone（LH）, estradiol（E₂）, androgen（T）, anti-mullerian hormone（AMH）, antral follicle number（AFC）, endometrial thickness（EMT） and peak systolic velocity（PSV） were compared between the two groups before and after medication. The ovulation induction pregnancy outcome was followed up.Results There were no statistical differences in FSH, LH, T, AMH and AFC levels in progynova group and femoston group before and after medication（all P>0.05）. After treatment, the level of E₂ in the two groups was higher than that before treatment, and the values of EMT and PSV were both higher than those before treatment（all P<0.05）. After treatment, the levels of FSH, LH, T, AMH and AFC in femoston group were not statistically different from those in progynova group（all P>0.05）. After treatment, the level of E₂ in femoston group was higher than that in progynova group, and the values of EMT and PSV were both higher than those in progynova group（all P<0.05）. The pregnancy rate（53.3%, 16/30） in femoston group was higher than that in progynova group（26.7%, 8/30）（P<0.05）.Conclusion Femoston estrogen vaginal administration is an effective pretreatment regimen to enhance EMT in PCOS infertile patients with thin endometrium, which is helpful to increase the level of serum estrogen of patients, and ovulation induction therapy is conducive to improving pregnancy outcome.更多还原