【摘要】 目的探讨孕中期孕妇血清中游离β-人绒毛膜促性腺激素（fβ-hCG）、血浆抑制素A（INH-A）及游离雌三醇（uE3）水平变化与妊娠期高血压疾病（HDP）的相关性。方法对2017年12月至2018年12月在郑州大学第一附属医院妇产科就诊的30例HDP孕妇（HDP组）和同期79例健康体检的孕妇（正常妊娠组）资料进行回顾性分析。所有入组孕妇均在孕16～20周行fβ-hCG、INH-A及uE3水平检测,且定期产检直至分娩后。比较两组孕妇血清fβ-hCG、INH-A、uE3水平,并分析各血清指标与妊娠结局的相关性。结果孕16～20周时,HDP组fβ-hCG、INH-A水平高于正常妊娠组,uE3水平低于正常妊娠组,差异有统计学意义（均P<0.05）。血清fβ-hCG水平与新生儿1 min Apgar评分呈负相关（r=-0.619,P=0.026）;血清INH-A水平与新生儿出生体质量及1 min Apgar评分呈负相关（r₁=-0.762,P₁=0.014;r₂=-0.518,P₂=0.048）;血清uE3水平与分娩孕周呈正相关（r=0.836,P=0.012）。结论血清fβ-hCG、INH-A及uE3在HDP的发病中至关重要,可作为预测HDP发生的敏感指标。更多还原

【Abstract】 Objective To discuss the correlation between serum levels of free human chorionic gonadotropin（fβ-hCG）, serum inhibin A（INH-A） and free estriol（uE3） in the second trimester and hypertensive disorders of pregnancy.Methods A retrospective analysis was performed on 30 HDP pregnant women（HDP group） and 79 healthy pregnant women（normal pregnancy group） who visited the department of obstetrics and gynecology of the First Affiliated Hospital of Zhengzhou University from December 2017 to December 2018. All enrolled pregnant women underwent fβ-hCG, INH-A and uE3 levels testing at 16-20 weeks of pregnancy, and received regular prenatal examinations until after delivery. Serum fβ-hCG, INH-A, uE3 levels were compared between the two groups of pregnant women, and the correlation of each serum index with pregnancy outcome was analyzed.Results At 16-20 weeks of pregnancy, serum fβ-hCG, INH-A levels in HDP group were higher than those in normal pregnancy group, and uE3 level was lower than that in normal pregnancy group, the differences were statistically significant（all P<0.05）. Serum fβ-hCG level was negatively correlated with neonatal 1 min Apgar score（r=-0.619,P=0.026）; serum INH-A level was negatively correlated with neonatal body mass and 1 min Apgar score（r₁=-0.762,P₁=0.014;r₂=-0.518,P₂=0.048）; serum uE3 level was positively correlated with delivery week（r=0.836,P=0.012）.Conclusion Serum fβ-hCG, INH-A and uE3 are important in the pathogenesis of HDP and can be used as sensitive indicators to predict the occurrence of HDP.更多还原