【摘要】 目的:探讨口服替诺福韦治疗艾滋病后对患者外周血心型肌酸激酶(CK-MB)活性检测的影响。方法:采用回顾性研究方法,选取2019年9月～2019年12月期间长沙市第一医院HIV门诊经治患者170例,根据治疗药物中是否含富马酸替诺福韦二吡呋酯(TDF)分为TDF组和非TDF组,比较两组之间的CK-MB活性和CK-MB质量浓度,并分别对两组的CK-MB活性和CK-MB质量浓度进行相关性分析。结果:TDF组CK-MB活性明显高于非TDF组,两组间CK-MB质量浓度差异无显著性;非TDF组CK-MB活性与CK-MB质量浓度相关系数为0.963,TDF组CK-MB活性与CK-MB质量浓度相关系数为0.094。结论:替诺福韦治疗艾滋病导致患者免疫抑制法检测的CK-MB活性假性升高。更多还原

【Abstract】 Objective To investigate the effect of tenofovir application on Creatine kinase-MB (CK-MB) activity detection in HIV infected patients.Methods A retrospective study was conducted among 170 treated outpatients who visited the HIV Clinic of The first hospital of Changsha from Sep 2019 to Dec 2019.According to tenofovir dipivoxil fumarate (TDF) was included in the chemotherapy protocol or not,they were divided into TDF group and non-TDF group.The CK-MB activity and the CK-MB mass concentration were compared between the two groups.Meanwhile,the correlations between CK-MB activity and CK-MB mass concentration in each group were analyzed.Results The CK-MB activity of TDF group was higher than that of non-TDF group,while there was no significant difference in CK-MB mass concentration between TDF group and non-TDF group.The correlation coefficients of CK-MB activity to CK-MB mass concentration in non-TDF group and TDF group were 0.963 and 0.094 respectively.Conclusion Treatment of HIV infection with tenofovir leads to pseudoelevation of serum CK-MB activity detected by immunosuppression method.更多还原