【摘要】 目的:探讨液基细胞学检查联合血清SCCA水平检测在宫颈癌癌前病变诊断中的诊断价值。方法:选取在2015年1月～2018年1月期间进行宫颈疾病筛查的630例患者作为研究对象,回顾性分析其临床检验资料。其中210例患者接受液基细胞学检查,210例患者接受血清SCCA水平检测,而剩下210例患者接受液基细胞学检查联合血清SCCA水平检测诊断。最后将上述三类检测方法的诊断结果与组织病理学诊断结果进行比较,分析联合检测方法的诊断效果。结果:液基细胞学检查结果阳性符合率为42.86%,该检查手段诊断特异度与敏感度分别为75.00%、83.33%;血清SCCA水平检查结果阳性符合率为33.33%,该检查手段诊断特异度与敏感度分别为74.68%、93.33%;联合检查阳性符合率为93.33%,该检查手段诊断特异度与敏感度分别为99.44%、90.00%;液基细胞学检查联合血清SCCA水平检测阳性符合率和特异度最高,且ROC曲线下面积最大。结论:液基细胞学检查联合血清SCCA水平检测用于宫颈癌癌前病变诊断,能有效提高疾病阳性检测率与特异度。因此,该方法值得在临床上进一步推广与应用。更多还原

【Abstract】 Objective To evaluate the diagnostic value of liquid-based cytology combined with serum SCCA level in the diagnosis of cervical precancerous lesions.Methods The clinical data of 630 patients who were screened for cervical diseases from January 2015 to January 2018 were retrospectively analyzed.Among them,210 cases were examined by liquid-based cytology,210 cases by serum SCCA,and the remaining 210 cases by liquid-based cytology combined with serum SCCA.Finally,the diagnosis results and histopathological diagnosis of the above three detection methods were summarized.The results were compared and the diagnostic effect of the combined detection method was analyzed.Results The positive coincidence rate of liquid-based cytology was 42.86.The diagnostic specificity and sensitivity of the method were 75.00 and 83.33,respectively.The positive coincidence rate of serum SCCA level was 33.33.The diagnostic specificity and sensitivity of this method were 74.68 and 93.33 respectively.The positive coincidence rate of combined examination was 93.33,the diagnostic specificity and sensitivity of this method were 99.444.00 and 90.The combination of liquid-based cytology and serum SCCA was positive.The sex coincidence rate and specificity were the highest,and the area under ROC curve was the largest.Conclusion Liquid based cytology combined with serum SCCA detection can effectively improve the positive detection rate and specificity of cervical precancerous lesions.Therefore,this method is worthy of further promotion and application in clinical practice.更多还原