【摘要】 目的探讨神经内镜经鼻入路治疗侵袭性垂体腺瘤切除程度的危险因素。方法收集2016-09—2019-06郑州大学第一附属医院神经外科治疗的侵袭性垂体腺瘤患者,回顾分析不同患者性别与年龄、肿瘤的Knosp分级、单侧或双侧海绵窦侵袭、大小与位置(鞍上或蝶窦)、质地、切除程度。结果单因素分析显示,肿瘤的Knosp分级与单双侧侵袭、体积大小与位置、肿瘤质地是影响切除程度的危险因素。多因素Logistic回归分析显示,Knosp分级、肿瘤大小与肿瘤质地为影响切除程度的独立危险因素。结论术前分析肿瘤Knosp分级与肿瘤大小,术中评估肿瘤质地,熟练操作与应用技巧,有助于提高切除程度。更多还原

【Abstract】 Objective To explore the risk factors of resection degree of invasive pituitary adenoma treated with endoscopic endonasal transsphenoidal approach.Methods Patients with invasive pituitary adenoma treated with neurosurgery in the First Affiliated Hospital of Zhengzhou University from September 2016 to June 2019 were retrospectively analyzed by gender and age,Knosp classification of tumor,unilateral or bilateral cavernous sinus invasion,size and position(upper saddle or sphenoid sinus),texture,degree of resection.Results Univariate analysis showed that Knosp grade,single or bilateral invasion,size,location and texture were risk factors influencing the degree of resection.Multivariate Logistic regression analysis showed that Knosp grade,tumor size and tumor texture were independent risk factors for the degree of resection.Conclusion Preoperative analysis of tumor Knosp grading and tumor size,intraoperative evaluation of tumor texture,experienced operation and applied skills can help improve the degree of resection.更多还原