【摘要】 目的探讨催乳素、血管内皮生长因子与乳腺癌的分期、病理类型、分子分型的关系。方法收集2015-01—2019-08间郑州大学第一附属医院758例乳腺癌患者的临床资料,同时选取该时间段诊断为良性乳腺疾病的500例患者作为对照组。分析催乳素、血管内皮生长因子在乳腺癌患者与良性乳腺疾病患者,以及不同类型乳腺癌患者中的差异。结果乳腺癌患者的催乳素、血管内皮生长因子均高于对照组(P均<0.001),其中分期≥Ⅱ期的患者明显高于<Ⅱ期的患者(P<0.001)。浸润性乳腺癌患者的催乳素、血管内皮生长因子高于非浸润性乳腺癌患者(P<0.001)。Luminal A型及B型患者的催乳素明显高于ERBB2+型及Basal-like型,ERBB2+型及Basal-like型患者的血管内皮生长因子明显高于LuminalA型和B型(P均<0.001)。结论血管内皮生长因子和催乳素与乳腺癌的分期、病理类型、分子分型有关。分期越高,浸润性越强,两者的值越高。在临床工作中应给予足够重视。更多还原

【Abstract】 Objective To explore the relationship between prolactin, vascular endothelial growth factor and the staging, pathological types and molecular subtypes of breast cancer.Methods The clinical data of 758 patients with breast cancer in the First Affiliated Hospital of Zhengzhou University from January 2015 to August 2019 were collected. And 500 patients diagnosed with benign breast diseases in this period were selected as control group. To analyze the difference of prolactin and vascular endothelial growth factor between breast cancer patients and benign disease patients and different types of breast cancer patients.Results The levels of prolactin and vascular endothelial growth factor in breast cancer patients were higher than those of control group(P<0.001), and those in the patients with stage(≥Ⅱ) were significantly higher than those with stage(<Ⅱ)(P<0.001).Prolactin and vascular endothelial growth factor in invasive breast cancer patients were higher than those of noninvasive breast cancer patients(P<0.001).Prolactin levels in patients with luminal A and B were significantly higher than those of patients with ERBB2 + and Basal-like. Vascular endothelial growth factor levels of patients with ERBB2 + and Basal-like were significantly higher than those of patients with luminal A and B(P<0.001).Conclusion Prolactin and vascular endothelial growth factor are related to the staging, pathological types and molecular subtypes of breast cancer. The higher the staging and the stronger the infiltration, the higher the value of both, we should pay enough attention to them in clinical work.更多还原