【摘要】 目的:探究磁共振动态（DCE-MRI）增强定量参数与容积转运常数(K^trans)对克罗恩病（CD）病情的评估效果。方法:选取某院接受治疗的50例克罗恩病患者,对患者分别进行MRI、DCE-MEI扫描和K^trans值测量,同时收集患者的HBI和ADC等各项资料。将50例患者根据HBI水平分为重度活动组10例、轻中度活动组22例和静止组18例,对3组患者的K^trans、ADC进行比较,分析活动期和慢性期CD患者MRI表现及K^trans、ADC、HBI的相关性。结果:3组患者K^trans值、ADC值比较,差异有统计学意义（P<0.05）;MRI诊断CD的结果显示:假阳性患者5例,假阴性患者23例,敏感度为66.2%,特异度为84.4%,阳性预测值为90.0%,阴性预测值为54.0%;Spearman和Pearson相关性分析显示:50例CD患者的K^trans与HBI呈现正相关,与ADC呈现负相关,血清ADC与K^trans呈现负相关（P均<0.05）。结论:MRI定量参数K^trans在反应CD活动状态方面有重要作用,具有一定的临床应用价值。更多还原

【Abstract】 Objective: To investigate the effect of dynamic-contrast enhanced magnetic resonance imaging（DCE-MRI） on quantitative assessment of Crohn’s disease（CD）.Methods: 50 patients with CD were selected for routine MRI and DCE-MRI scanning. K^trans was measured and the patients’ HBI and C-reactive protein（CRP） and other general information were collected. The 50 patients were divided into a severe activity group（10 cases）, a mild to moderate group（22 cases） and a static group（18 cases） according to HBI level. The K^trans and ADC of the three groups were compared to analyze the MRI findings of active and chronic CD patients and correlations between K^trans, ADC and HBI.Results: In comparison of K^trans and ADC between the three groups of patients, the difference was statistically significant（P<0.05）. The findings of MRI diagnosed CD indicated that there were 5 false positive cases, 23 false negative cases, 45 true positive cases and 27 true negative cases.The result of DCE-MRI assessmerit revealed that the sensitivity was 66.2%, the specificity 84.4%, the positive predictive value 90.0%, and the negative predictive value 54.0%. Correlation analysis of Spearman and Pearson showed that K^trans of the 50 CD patients were positively correlated with HBI and negatively correlated with ADC and serum ADC indicated negative correlation with K^trans（P<0.05）.Conclusion: Quantitative parameter K^trans of MRI plays an important role in CD activity, and has a high clinical value.更多还原