【摘要】 目的:分析老年高血压患者血清尿酸(UA)、肌酸激酶(CK)、胱抑素C(Cys-C)、脂联素(APN)水平与颈动脉粥样硬化之间的关系。方法:选择我院2018年4月至2019年4月收治的老年高血压患者110例为研究对象,根据患者颈动脉内膜中层厚度(IMT)分为IMT正常组(36例)、IMT增厚组(31例)、斑块形成组(43例)三组,检测患者血清UA、CK、Cys-C、APN水平,分析IMT与上述指标的相关性,并对影响老年高血压患者颈动脉粥样硬化的因素进行Logistic回归模型分析。结果:随着IMT增厚程度增加,血清UA、CK、Cys-C水平逐渐升高,其水平IMT正常组<IMT增厚组<斑块形成组(P<0.05),APN水平逐渐降低,其水平IMT正常组>IMT增厚组>斑块形成组(P <0.05); Pearson相关性分析显示,IMT与UA、CK、Cys-C呈正相关(P<0.05),与APN呈负相关(P<0.05);二元Logistic回归模型分析,结果显示,血清UA、CK、Cys-C、APN是影响老年高血压患者颈动脉粥样硬化的独立危险因素(P<0.05)。结论:老年高血压患者颈动脉粥样硬化程度与血清UA、CK、Cys-C水平升高以及APN水平降低有关。更多还原

【Abstract】 Objective: To analyze the relationship between levels of serum uric acid( UA),creatine kinase( CK),cystatin C( Cys-C),adiponectin( APN) and carotid atherosclerosis in elderly patients with hypertension. Methods: A total of 110 elderly patients with hypertension admitted to our hospital from April2018 to April 2019 were selected for the study. The patients were divided into normal IMT group( 36 cases),IMT thickening group( 31 cases) and plaque formation group( 43 cases) according to the carotid intima-media thickness( IMT). The levels of serum UA,CK,Cys-C and APN were detected,and the correlation between IMT and above indicators was analyzed,and the factors affecting carotid atherosclerosis in elderly hypertensive patients were analyzed by Logistic regression model. Results: With the increase of IMT thickening,the levels of serum UA,CK and Cys-C were increased gradually,and the levels showed normal IMT group<IMT thickening group<plaque formation group( P <0.05),and the APN level was gradually decreased,and the level showed normal IMT group>IMT thickening group>plaque formation group( P <0.05). Pearson correlation analysis showed that IMT was positively correlated with UA,CK and Cys-C( P <0.05),and was negatively correlated with APN( P <0.05). Binary Logistic regression model analysis showed that serum UA,CK,Cys-C and APN were independent risk factors for carotid atherosclerosis in elderly hypertensive patients( P <0.05). Conclusion: The degree of carotid atherosclerosis in elderly hypertensive patients is related to the increases of serum UA,CK and Cys-C and the decrease of APN.更多还原