【摘要】 目的:探究人巨细胞病毒(HCMV)感染对2型糖尿病患者糖代谢、C肽及胰岛素敏感性的影响。方法:将我院2016年2月至2018年2月收治的154例2型糖尿病患者纳入T2DM组,另择50例同期于我院查体排除糖尿病的健康成年人纳入对照组。测定并分析受试者HCMV-DNA病毒载量、空腹血糖(FPG)、C肽(C-P)、空腹胰岛素(Fins)、胰岛素敏感指数(ISI)及T淋巴细胞亚群情况。结果:T2DM组及对照组受试者HCMV-DNA阳性率分别为50.64%及26.00%; T2DM组患者HCMV-DNA载量显著高于对照组(P <0.05);与健康对照组相比,T2DM组患者伴有FPG、CD4+淋巴细胞比例及CD4+/CD8+比值升高,Fins、C-P、ISI及CD8+T淋巴细胞比例降低(P <0.05); HCMV-DNA阳性患者各指标升高或上升幅度显著大于HCMV-DNA阴性患者(P<0.05)。结论:HCMV病毒感染可导致2型糖尿病患者糖代谢异常,降低胰岛素敏感性,加重机体免疫失衡症状,促进病情的进展。更多还原

【Abstract】 Objective: To investigate the effects of human cytomegalovirus( HCMV) infection on glucose metabolism,C-peptide and insulin sensitivity in patients with type 2 diabetes mellitus( T2 DM). Methods: 154 patients with T2 DM admitted to the hospital during the period from February 2016 to February 2018 were included in the T2 DM group. 50 healthy adults were included in the control group. The HCMV-DNA viral load,fasting plasma Glucose( FPG),C-peptide( C-P),fasting insulin( Fins),insulin sensitivity index( ISI) and T lymphocyte subsets in all subjects were determined and analyzed. Results: The positive rates of HCMV-DNA in the T2 DM group and the control group were 50.64% and 26.00%,respectively. The HCMVDNA load in the T2 DM group was significantly higher than that in the control group( P <0.05). The FPG,ratio of CD4+ lymphocytes and CD4+/CD8+ ratio were increased,the Fins,CP,ISI and ratio of CD8+ T lymphocytes were decreased in the T2 DM group,compared with the control group( P <0.05). The increase or increase of each index in HCMV-DNA positive patients was significantly greater than that in HCMV-DNA negative patients( P <0.05). Conclusion: HCMV infection can cause abnormal glucose metabolism in patients with T2 DM,reduce insulin sensitivity,aggravate immune imbalance,and promote the progression of the disease.更多还原