【摘要】 目的联合应用高场强磁共振灌注（PWI）和扩散加权成像（DWI）技术,探讨其对肉芽肿性乳腺炎与乳腺癌的鉴别诊断价值。方法回顾性分析了36例患者病理已证实为肉芽肿性乳腺炎或乳腺癌的共36个乳腺病灶行乳腺MRI（T2WI、PWI和DWI）检查,选取的所有病变在T2WI压脂序列均为高信号,分别测量这些病变区域的PWI参数和DWI序列的ADC值,其中b值分别取0和800 mm²/s。并按病理结果将其分为肉芽肿性乳腺炎组与乳腺癌组,对2组的病理结果和磁共振特征应用单因素方差分析进行统计学分析。结果肉芽肿性乳腺炎组与乳腺癌组的平均ADC值（0.76±0.15）,（1.18±0.35）10^-3mm²/s。肉芽肿性乳腺炎组的ADC值显著低于乳腺癌组（P<0.05）。2组间的灌注定量参数平均Ktrans、Kep值差异具有统计学意义（P<0.01）。结论联合应用磁共振PWI和DWI技术对肉芽肿性乳腺炎和乳腺癌具有鉴别诊断价值。更多还原

【Abstract】 Objective To investigate the value of magnetic resonance perfusion imaging（PWI） and diffusion-weighted imaging（DWI） in differential diagnosis between granulomatous mastitis and breast cancer.Methods The examination results of MRI（T2 WI、PWI and DWI） for 36 patients who were diagnosed by pathological examination as granulomatous mastitis or breast cancer were retrospectively analyzed, which were high signal in T2 WI sequences,and PWI parameters and ADC values of DWI sequence in these lesion areas were measured respectively,and B value was taken as 0 and 800 mm2/s.According to the pathological results,which were divided into granulomatous mastitis group and breast cancer group,and the pathological results and magnetic resonance characteristics were observed and statistically analyzed.Results The mean ADC values ±standard deviation of granulomatous mastitis group and breast cancer group were（0.76±0.15）,（1.18±0.35）10^-3mm²/s,respectively,and the ADC value in granulomatous mastitis group was significantly lower than that in breast cancer group（P<0.05）.There were significant differnces in the mean Ktrans and Kep values of perfusion quantitative parameters between the two groups（P<0.01）.Conclusion The combination application of PWI with DWI has differential diagnosis value between granulomatous mastitis and breast cancer.更多还原